diff --git a/lldb/source/Core/Section.cpp b/lldb/source/Core/Section.cpp
--- a/lldb/source/Core/Section.cpp
+++ b/lldb/source/Core/Section.cpp
@@ -267,11 +267,8 @@
   so_addr.SetOffset(offset);
   so_addr.SetSection(const_cast<Section *>(this)->shared_from_this());
 
-#ifdef LLDB_CONFIGURATION_DEBUG
-  // For debug builds, ensure that there are no orphaned (i.e., moduleless)
-  // sections.
+  // Ensure that there are no orphaned (i.e., moduleless) sections.
   assert(GetModule().get());
-#endif
   return true;
 }
 
diff --git a/lldb/source/Plugins/Process/MacOSX-Kernel/CommunicationKDP.cpp b/lldb/source/Plugins/Process/MacOSX-Kernel/CommunicationKDP.cpp
--- a/lldb/source/Plugins/Process/MacOSX-Kernel/CommunicationKDP.cpp
+++ b/lldb/source/Plugins/Process/MacOSX-Kernel/CommunicationKDP.cpp
@@ -77,11 +77,9 @@
   }
 
   std::lock_guard<std::recursive_mutex> guard(m_sequence_mutex);
-#ifdef LLDB_CONFIGURATION_DEBUG
   // NOTE: this only works for packets that are in native endian byte order
   assert(request_packet.GetSize() ==
          *((const uint16_t *)(request_packet.GetData() + 2)));
-#endif
   lldb::offset_t offset = 1;
   const uint32_t num_retries = 3;
   for (uint32_t i = 0; i < num_retries; ++i) {
diff --git a/lldb/source/Plugins/Process/gdb-remote/GDBRemoteRegisterContext.h b/lldb/source/Plugins/Process/gdb-remote/GDBRemoteRegisterContext.h
--- a/lldb/source/Plugins/Process/gdb-remote/GDBRemoteRegisterContext.h
+++ b/lldb/source/Plugins/Process/gdb-remote/GDBRemoteRegisterContext.h
@@ -88,9 +88,7 @@
   void SetAllRegisterValid(bool b);
 
   bool GetRegisterIsValid(uint32_t reg) const {
-#if defined(LLDB_CONFIGURATION_DEBUG)
     assert(reg < m_reg_valid.size());
-#endif
     if (reg < m_reg_valid.size())
       return m_reg_valid[reg];
     return false;
@@ -103,9 +101,7 @@
   }
 
   void SetRegisterIsValid(uint32_t reg, bool valid) {
-#if defined(LLDB_CONFIGURATION_DEBUG)
     assert(reg < m_reg_valid.size());
-#endif
     if (reg < m_reg_valid.size())
       m_reg_valid[reg] = valid;
   }