diff --git a/llvm/lib/Transforms/Scalar/AlignmentFromAssumptions.cpp b/llvm/lib/Transforms/Scalar/AlignmentFromAssumptions.cpp
--- a/llvm/lib/Transforms/Scalar/AlignmentFromAssumptions.cpp
+++ b/llvm/lib/Transforms/Scalar/AlignmentFromAssumptions.cpp
@@ -127,6 +127,11 @@
                                 const SCEV *OffSCEV, Value *Ptr,
                                 ScalarEvolution *SE) {
   const SCEV *PtrSCEV = SE->getSCEV(Ptr);
+  // On a platform with 32-bit allocas, but 64-bit flat/global pointer sizes
+  // (*cough* AMDGPU), the effective SCEV type of AASCEV and PtrSCEV
+  // may disagree. Trunc/extend so they agree.
+  PtrSCEV = SE->getTruncateOrZeroExtend(
+      PtrSCEV, SE->getEffectiveSCEVType(AASCEV->getType()));
   const SCEV *DiffSCEV = SE->getMinusSCEV(PtrSCEV, AASCEV);
 
   // On 32-bit platforms, DiffSCEV might now have type i32 -- we've always
diff --git a/llvm/test/Transforms/AlignmentFromAssumptions/amdgpu-crash.ll b/llvm/test/Transforms/AlignmentFromAssumptions/amdgpu-crash.ll
new file mode 100644
--- /dev/null
+++ b/llvm/test/Transforms/AlignmentFromAssumptions/amdgpu-crash.ll
@@ -0,0 +1,46 @@
+; Test that we don't crash.
+; RUN: opt < %s -alignment-from-assumptions -S | FileCheck %s
+; RUN: opt < %s -passes=alignment-from-assumptions -S | FileCheck %s
+
+target datalayout = "e-p:64:64-p1:64:64-p2:32:32-p3:32:32-p4:64:64-p5:32:32-p6:32:32-i64:64-v16:16-v24:32-v32:32-v48:64-v96:128-v192:256-v256:256-v512:512-v1024:1024-v2048:2048-n32:64-S32-A5-ni:7"
+
+%"core::str::CharIndices.29.66.90.114.138.149.165.173.181.197.205.213.229.387.398" = type { [0 x i64], i64, [0 x i64], { i8*, i8* }, [0 x i64] }
+%"unwind::libunwind::_Unwind_Exception.9.51.75.99.123.147.163.171.179.195.203.211.227.385.396" = type { [0 x i64], i64, [0 x i64], void (i32, %"unwind::libunwind::_Unwind_Exception.9.51.75.99.123.147.163.171.179.195.203.211.227.385.396"*)*, [0 x i64], [6 x i64], [0 x i64] }
+%"unwind::libunwind::_Unwind_Context.10.52.76.100.124.148.164.172.180.196.204.212.228.386.397" = type { [0 x i8] }
+
+define dso_local void @"_ZN44_$LT$$RF$T$u20$as$u20$core..fmt..Display$GT$3fmt17h7b1d039c7ff5e1feE"() unnamed_addr #0 {
+start:
+  %_15.i.i = alloca %"core::str::CharIndices.29.66.90.114.138.149.165.173.181.197.205.213.229.387.398", align 8, addrspace(5)
+  br label %bb12.i.i
+
+bb12.i.i:                                         ; preds = %start
+  %0 = addrspacecast %"core::str::CharIndices.29.66.90.114.138.149.165.173.181.197.205.213.229.387.398" addrspace(5)* %_15.i.i to %"core::str::CharIndices.29.66.90.114.138.149.165.173.181.197.205.213.229.387.398"*
+  %ptrint53.i.i = ptrtoint %"core::str::CharIndices.29.66.90.114.138.149.165.173.181.197.205.213.229.387.398"* %0 to i64
+  %maskedptr54.i.i = and i64 %ptrint53.i.i, 7
+  %maskcond55.i.i = icmp eq i64 %maskedptr54.i.i, 0
+  call void @llvm.assume(i1 %maskcond55.i.i) #1
+  br i1 undef, label %bb20.i.i, label %bb3.i.i.i.i.i.preheader.i.i
+
+bb3.i.i.i.i.i.preheader.i.i:                      ; preds = %bb12.i.i
+  %1 = getelementptr inbounds %"core::str::CharIndices.29.66.90.114.138.149.165.173.181.197.205.213.229.387.398", %"core::str::CharIndices.29.66.90.114.138.149.165.173.181.197.205.213.229.387.398"* %0, i64 0, i32 0, i64 0
+  store i64 0, i64* %1, align 8, !noalias !1
+  unreachable
+
+bb20.i.i:                                         ; preds = %bb12.i.i
+  ret void
+}
+
+; Function Attrs: nounwind
+declare void @llvm.assume(i1) #1
+
+attributes #0 = { "target-features"="+dpp,+s-memrealtime,+code-object-v3,+16-bit-insts" }
+attributes #1 = { nounwind }
+
+!llvm.module.flags = !{!0}
+
+!0 = !{i32 2, !"RtLibUseGOT", i32 1}
+!1 = !{!2, !4}
+!2 = distinct !{!2, !3, !"_ZN4core3fmt9Formatter3pad17haf5ef419967c4e14E: argument 0"}
+!3 = distinct !{!3, !"_ZN4core3fmt9Formatter3pad17haf5ef419967c4e14E"}
+!4 = distinct !{!4, !5, !"_ZN42_$LT$str$u20$as$u20$core..fmt..Display$GT$3fmt17h4b7a4f3a0a4d2185E: %self.0"}
+!5 = distinct !{!5, !"_ZN42_$LT$str$u20$as$u20$core..fmt..Display$GT$3fmt17h4b7a4f3a0a4d2185E"}