diff --git a/clang/lib/Driver/ToolChains/Clang.cpp b/clang/lib/Driver/ToolChains/Clang.cpp
--- a/clang/lib/Driver/ToolChains/Clang.cpp
+++ b/clang/lib/Driver/ToolChains/Clang.cpp
@@ -6396,6 +6396,7 @@
                            codegenoptions::DebugInfoKind *DebugInfoKind,
                            bool *EmitCodeView) const {
   unsigned RTOptionID = options::OPT__SLASH_MT;
+  bool isNVPTX = getToolChain().getTriple().isNVPTX();
 
   if (Args.hasArg(options::OPT__SLASH_LDd))
     // The /LDd option implies /MTd. The dependent lib part can be overridden,
@@ -6463,8 +6464,8 @@
 
   // This controls whether or not we emit stack-protector instrumentation.
   // In MSVC, Buffer Security Check (/GS) is on by default.
-  if (Args.hasFlag(options::OPT__SLASH_GS, options::OPT__SLASH_GS_,
-                   /*Default=*/true)) {
+  if (!isNVPTX && Args.hasFlag(options::OPT__SLASH_GS, options::OPT__SLASH_GS_,
+                               /*Default=*/true)) {
     CmdArgs.push_back("-stack-protector");
     CmdArgs.push_back(Args.MakeArgString(Twine(LangOptions::SSPStrong)));
   }
@@ -6484,7 +6485,7 @@
 
   const Driver &D = getToolChain().getDriver();
   EHFlags EH = parseClangCLEHFlags(D, Args);
-  if (EH.Synch || EH.Asynch) {
+  if (!isNVPTX && (EH.Synch || EH.Asynch)) {
     if (types::isCXX(InputType))
       CmdArgs.push_back("-fcxx-exceptions");
     CmdArgs.push_back("-fexceptions");
@@ -6553,7 +6554,7 @@
                           options::OPT__SLASH_Gregcall)) {
     unsigned DCCOptId = CCArg->getOption().getID();
     const char *DCCFlag = nullptr;
-    bool ArchSupported = true;
+    bool ArchSupported = !isNVPTX;
     llvm::Triple::ArchType Arch = getToolChain().getArch();
     switch (DCCOptId) {
     case options::OPT__SLASH_Gd:
diff --git a/clang/test/Driver/cl-options.cu b/clang/test/Driver/cl-options.cu
new file mode 100644
--- /dev/null
+++ b/clang/test/Driver/cl-options.cu
@@ -0,0 +1,27 @@
+// Verify that we don't pass unwanted options to device-side compilation when
+// clang-cl is used for CUDA compilation.
+// Note: %s must be preceded by --, otherwise it may be interpreted as a
+// command-line option, e.g. on Mac where %s is commonly under /Users.
+
+// -stack-protector should not be passed to device-side CUDA compilation
+// RUN: %clang_cl -### -nocudalib -nocudainc -- %s 2>&1 | FileCheck -check-prefix=GS-default %s
+// GS-default: "-cc1" "-triple" "nvptx64-nvidia-cuda"
+// GS-default-NOT: "-stack-protector"
+// GS-default: "-cc1" "-triple"
+// GS-default: "-stack-protector" "2"
+
+// -exceptions should be passed to device-side compilation.
+// RUN: %clang_cl /c /GX -### -nocudalib -nocudainc -- %s 2>&1 | FileCheck -check-prefix=GX %s
+// GX: "-cc1" "-triple" "nvptx64-nvidia-cuda"
+// GX-NOT: "-fcxx-exceptions"
+// GX-NOT: "-fexceptions"
+// GX: "-cc1" "-triple"
+// GX: "-fcxx-exceptions" "-fexceptions"
+
+// /Gd should not override default calling convention on device side.
+// RUN: %clang_cl /c /Gd -### -nocudalib -nocudainc -- %s 2>&1 | FileCheck -check-prefix=Gd %s
+// Gd: "-cc1" "-triple" "nvptx64-nvidia-cuda"
+// Gd-NOT: "-fcxx-exceptions"
+// Gd-NOT: "-fdefault-calling-conv=cdecl"
+// Gd: "-cc1" "-triple"
+// Gd: "-fdefault-calling-conv=cdecl"