Index: llvm/lib/Transforms/Scalar/SROA.cpp
===================================================================
--- llvm/lib/Transforms/Scalar/SROA.cpp
+++ llvm/lib/Transforms/Scalar/SROA.cpp
@@ -2519,6 +2519,8 @@
         NewLI->setAAMetadata(AATags);
       if (LI.isVolatile())
         NewLI->setAtomic(LI.getOrdering(), LI.getSyncScopeID());
+      if (NewLI->isAtomic())
+        NewLI->setAlignment(MaybeAlign(LI.getAlignment()));
 
       // Any !nonnull metadata or !range metadata on the old load is also valid
       // on the new load. This is even true in some cases even when the loads
@@ -2709,6 +2711,8 @@
       NewSI->setAAMetadata(AATags);
     if (SI.isVolatile())
       NewSI->setAtomic(SI.getOrdering(), SI.getSyncScopeID());
+    if (NewSI->isAtomic())
+      NewSI->setAlignment(MaybeAlign(SI.getAlignment()));
     Pass.DeadInsts.insert(&SI);
     deleteIfTriviallyDead(OldOp);
 
Index: llvm/test/Transforms/SROA/alignment.ll
===================================================================
--- llvm/test/Transforms/SROA/alignment.ll
+++ llvm/test/Transforms/SROA/alignment.ll
@@ -228,4 +228,19 @@
   ret void
 }
 
+%struct = type { i32, i32 }
+define dso_local i32 @pr45010(%struct* %A) {
+; CHECK-LABEL: @pr45010
+; CHECK: load atomic volatile i32, {{.*}}, align 4
+
+  %B = alloca %struct, align 4
+  %A.i = getelementptr inbounds %struct, %struct* %A, i32 0, i32 0
+  %B.i = getelementptr inbounds %struct, %struct* %B, i32 0, i32 0
+  %1 = load i32, i32* %A.i, align 4
+  store i32 %1, i32* %B.i, align 4
+  %2 = bitcast %struct* %B to i32*
+  %x = load atomic volatile i32, i32* %2 acquire, align 4
+  ret i32 %x
+}
+
 declare void @populate(i8*)