diff --git a/llvm/lib/Target/WebAssembly/WebAssemblyRegColoring.cpp b/llvm/lib/Target/WebAssembly/WebAssemblyRegColoring.cpp
--- a/llvm/lib/Target/WebAssembly/WebAssemblyRegColoring.cpp
+++ b/llvm/lib/Target/WebAssembly/WebAssemblyRegColoring.cpp
@@ -157,6 +157,10 @@
     Changed |= Old != New;
     UsedColors.set(Color);
     Assignments[Color].push_back(LI);
+    // If we reassigned the stack pointer, update the debug frame base info.
+    if (MFI.isFrameBaseVirtual() && MFI.getFrameBaseVreg() == Old) {
+      MFI.setFrameBaseVreg(New);
+    }
     LLVM_DEBUG(dbgs() << "Assigning vreg" << Register::virtReg2Index(LI->reg)
                       << " to vreg" << Register::virtReg2Index(New) << "\n");
   }