diff --git a/llvm/lib/Transforms/IPO/GlobalOpt.cpp b/llvm/lib/Transforms/IPO/GlobalOpt.cpp
--- a/llvm/lib/Transforms/IPO/GlobalOpt.cpp
+++ b/llvm/lib/Transforms/IPO/GlobalOpt.cpp
@@ -509,7 +509,7 @@
     }
   } else if (SequentialType *STy = dyn_cast<SequentialType>(Ty)) {
     unsigned NumElements = STy->getNumElements();
-    if (NumElements > 16 && GV->hasNUsesOrMore(16))
+    if (NumElements > 16)
       return nullptr; // It's not worth it.
     NewGlobals.reserve(NumElements);
     auto ElTy = STy->getElementType();
diff --git a/llvm/test/Transforms/GlobalOpt/long-compilation-global-sra.ll b/llvm/test/Transforms/GlobalOpt/long-compilation-global-sra.ll
new file mode 100644
--- /dev/null
+++ b/llvm/test/Transforms/GlobalOpt/long-compilation-global-sra.ll
@@ -0,0 +1,53 @@
+; RUN: opt %s --O0 -globalopt -S -o -
+
+; This is a regression test against very slow execution...
+; In bad case it should fail by timeout.
+
+; Hand-reduced from this example.
+; clang++ -mllvm -disable-llvm-optzns
+
+;#include <stdio.h>
+;
+;namespace {
+;  char LargeBuffer[64 * 1024 * 1024];
+;}
+;
+;int main ( void ) {
+;
+;    LargeBuffer[0] = 0;
+;
+;    printf("");
+;
+;    return LargeBuffer[0] == 0;
+;}
+
+; ModuleID = 'test.cpp'
+source_filename = "test.cpp"
+target datalayout = "e-m:e-p270:32:32-p271:32:32-p272:64:64-i64:64-f80:128-n8:16:32:64-S128"
+target triple = "x86_64-unknown-linux-gnu"
+
+@_ZN12_GLOBAL__N_111LargeBufferE = internal global [67108864 x i8] zeroinitializer, align 16
+@.str = private unnamed_addr constant [1 x i8] c"\00", align 1
+
+; Function Attrs: norecurse uwtable
+define dso_local i32 @main() #0 {
+  %1 = alloca i32, align 4
+  store i32 0, i32* %1, align 4
+  store i8 0, i8* getelementptr inbounds ([67108864 x i8], [67108864 x i8]* @_ZN12_GLOBAL__N_111LargeBufferE, i64 0, i64 0), align 16
+  %2 = call i32 (i8*, ...) @printf(i8* getelementptr inbounds ([1 x i8], [1 x i8]* @.str, i64 0, i64 0))
+  %3 = load i8, i8* getelementptr inbounds ([67108864 x i8], [67108864 x i8]* @_ZN12_GLOBAL__N_111LargeBufferE, i64 0, i64 0), align 16
+  %4 = sext i8 %3 to i32
+  %5 = icmp eq i32 %4, 0
+  %6 = zext i1 %5 to i32
+  ret i32 %6
+}
+
+declare dso_local i32 @printf(i8*, ...) #0
+
+attributes #0 = { norecurse uwtable }
+
+!llvm.module.flags = !{!0}
+!llvm.ident = !{!1}
+
+!0 = !{i32 1, !"wchar_size", i32 4}
+!1 = !{!"clang version 10.0.0 "}