diff --git a/lldb/source/API/CMakeLists.txt b/lldb/source/API/CMakeLists.txt
--- a/lldb/source/API/CMakeLists.txt
+++ b/lldb/source/API/CMakeLists.txt
@@ -111,6 +111,14 @@
   ${option_install_prefix}
 )
 
+# lib/pythonX.Y/dist-packages/lldb/_lldb.so is a symlink to lib/liblldb.so,
+# which depends on lib/libLLVM*.so (BUILD_SHARED_LIBS) or lib/libLLVM-10git.so
+# (LLVM_LINK_LLVM_DYLIB). Add an additional rpath $ORIGIN/../../../../lib so
+# that _lldb.so can be loaded from Python.
+if(LLDB_ENABLE_PYTHON AND (BUILD_SHARED_LIBS OR LLVM_LINK_LLVM_DYLIB) AND UNIX AND NOT APPLE)
+  set_property(TARGET liblldb APPEND PROPERTY INSTALL_RPATH "\$ORIGIN/../../../../lib${LLVM_LIBDIR_SUFFIX}")
+endif()
+
 if (MSVC)
   set_source_files_properties(SBReproducer.cpp PROPERTIES COMPILE_FLAGS /bigobj)
 endif()