diff --git a/lldb/source/API/CMakeLists.txt b/lldb/source/API/CMakeLists.txt
--- a/lldb/source/API/CMakeLists.txt
+++ b/lldb/source/API/CMakeLists.txt
@@ -111,6 +111,19 @@
   ${option_install_prefix}
 )
 
+# lib/pythonX.Y/dist-packages/lldb/_lldb.so is a symlink to lib/liblldb.so .
+# Add an additional rpath \$ORIGIN/../../../../lib so that _lldb.so can be
+# loaded from Python.
+if(LLDB_ENABLE_PYTHON AND BUILD_SHARED_LIBS AND UNIX)
+  if(LLVM_INSTALL_PREFIX AND NOT (LLVM_INSTALL_PREFIX STREQUAL CMAKE_INSTALL_PREFIX))
+    set(extra_libdir ${LLVM_LIBRARY_DIR})
+  elseif(LLVM_BUILD_LIBRARY_DIR)
+    set(extra_libdir ${LLVM_LIBRARY_DIR})
+  endif()
+  set(_install_rpath "\$ORIGIN/../lib${LLVM_LIBDIR_SUFFIX}" "\$ORIGIN/../../../../lib${LLVM_LIBDIR_SUFFIX}" ${extra_libdir})
+  set_target_properties(liblldb PROPERTIES INSTALL_RPATH "${_install_rpath}")
+endif()
+
 if (MSVC)
   set_source_files_properties(SBReproducer.cpp PROPERTIES COMPILE_FLAGS /bigobj)
 endif()