diff --git a/llvm/lib/Transforms/InstCombine/InstCombineLoadStoreAlloca.cpp b/llvm/lib/Transforms/InstCombine/InstCombineLoadStoreAlloca.cpp
--- a/llvm/lib/Transforms/InstCombine/InstCombineLoadStoreAlloca.cpp
+++ b/llvm/lib/Transforms/InstCombine/InstCombineLoadStoreAlloca.cpp
@@ -526,7 +526,7 @@
 
 /// Returns true if instruction represent minmax pattern like:
 ///   select ((cmp load V1, load V2), V1, V2).
-static bool isMinMaxWithLoads(Value *V) {
+static bool isMinMaxWithLoads(Value *V, Type *&LoadTy) {
   assert(V->getType()->isPointerTy() && "Expected pointer type.");
   // Ignore possible ty* to ixx* bitcast.
   V = peekThroughBitcast(V);
@@ -540,6 +540,7 @@
   if (!match(V, m_Select(m_Cmp(Pred, m_Instruction(L1), m_Instruction(L2)),
                          m_Value(LHS), m_Value(RHS))))
     return false;
+  LoadTy = L1->getType();
   return (match(L1, m_Load(m_Specific(LHS))) &&
           match(L2, m_Load(m_Specific(RHS)))) ||
          (match(L1, m_Load(m_Specific(RHS))) &&
@@ -585,13 +586,15 @@
   // size is a legal integer type.
   // Do not perform canonicalization if minmax pattern is found (to avoid
   // infinite loop).
+  Type *Dummy;
   if (!Ty->isIntegerTy() && Ty->isSized() &&
       !(Ty->isVectorTy() && Ty->getVectorIsScalable()) &&
       DL.isLegalInteger(DL.getTypeStoreSizeInBits(Ty)) &&
       DL.typeSizeEqualsStoreSize(Ty) &&
       !DL.isNonIntegralPointerType(Ty) &&
       !isMinMaxWithLoads(
-          peekThroughBitcast(LI.getPointerOperand(), /*OneUseOnly=*/true))) {
+          peekThroughBitcast(LI.getPointerOperand(), /*OneUseOnly=*/true),
+          Dummy)) {
     if (all_of(LI.users(), [&LI](User *U) {
           auto *SI = dyn_cast<StoreInst>(U);
           return SI && SI->getPointerOperand() != &LI &&
@@ -1323,7 +1326,14 @@
   auto *LI = cast<LoadInst>(SI.getValueOperand());
   if (!LI->getType()->isIntegerTy())
     return false;
-  if (!isMinMaxWithLoads(LoadAddr))
+  Type *CmpLoadTy;
+  if (!isMinMaxWithLoads(LoadAddr, CmpLoadTy))
+    return false;
+
+  // Make sure we're not changing the size of the load/store.
+  const auto &DL = IC.getDataLayout();
+  if (DL.getTypeStoreSizeInBits(LI->getType()) !=
+      DL.getTypeStoreSizeInBits(CmpLoadTy))
     return false;
 
   if (!all_of(LI->users(), [LI, LoadAddr](User *U) {
@@ -1335,8 +1345,7 @@
     return false;
 
   IC.Builder.SetInsertPoint(LI);
-  LoadInst *NewLI = combineLoadToNewType(
-      IC, *LI, LoadAddr->getType()->getPointerElementType());
+  LoadInst *NewLI = combineLoadToNewType(IC, *LI, CmpLoadTy);
   // Replace all the stores with stores of the newly loaded value.
   for (auto *UI : LI->users()) {
     auto *USI = cast<StoreInst>(UI);
diff --git a/llvm/test/Transforms/InstCombine/PR37526.ll b/llvm/test/Transforms/InstCombine/PR37526.ll
--- a/llvm/test/Transforms/InstCombine/PR37526.ll
+++ b/llvm/test/Transforms/InstCombine/PR37526.ll
@@ -3,11 +3,14 @@
 
 define void @PR37526(i32* %pz, i32* %px, i32* %py) {
 ; CHECK-LABEL: @PR37526(
+; CHECK-NEXT:    [[T1:%.*]] = bitcast i32* [[PZ:%.*]] to i64*
 ; CHECK-NEXT:    [[T2:%.*]] = load i32, i32* [[PY:%.*]], align 4
 ; CHECK-NEXT:    [[T3:%.*]] = load i32, i32* [[PX:%.*]], align 4
 ; CHECK-NEXT:    [[CMP:%.*]] = icmp slt i32 [[T2]], [[T3]]
-; CHECK-NEXT:    [[R1:%.*]] = select i1 [[CMP]], i32 [[T3]], i32 [[T2]]
-; CHECK-NEXT:    store i32 [[R1]], i32* [[PZ:%.*]], align 4
+; CHECK-NEXT:    [[SELECT:%.*]] = select i1 [[CMP]], i32* [[PX]], i32* [[PY]]
+; CHECK-NEXT:    [[BC:%.*]] = bitcast i32* [[SELECT]] to i64*
+; CHECK-NEXT:    [[R:%.*]] = load i64, i64* [[BC]], align 4
+; CHECK-NEXT:    store i64 [[R]], i64* [[T1]], align 4
 ; CHECK-NEXT:    ret void
 ;
   %t1 = bitcast i32* %pz to i64*