diff --git a/clang/lib/Frontend/CompilerInstance.cpp b/clang/lib/Frontend/CompilerInstance.cpp
--- a/clang/lib/Frontend/CompilerInstance.cpp
+++ b/clang/lib/Frontend/CompilerInstance.cpp
@@ -917,8 +917,9 @@
   if (!hasTarget())
     return false;
 
-  // Create TargetInfo for the other side of CUDA and OpenMP compilation.
-  if ((getLangOpts().CUDA || getLangOpts().OpenMPIsDevice) &&
+  // Create TargetInfo for the other side of CUDA/OpenMP/SYCL compilation.
+  if ((getLangOpts().CUDA || getLangOpts().OpenMPIsDevice ||
+       getLangOpts().SYCLIsDevice) &&
       !getFrontendOpts().AuxTriple.empty()) {
     auto TO = std::make_shared<TargetOptions>();
     TO->Triple = llvm::Triple::normalize(getFrontendOpts().AuxTriple);
diff --git a/clang/lib/Frontend/InitPreprocessor.cpp b/clang/lib/Frontend/InitPreprocessor.cpp
--- a/clang/lib/Frontend/InitPreprocessor.cpp
+++ b/clang/lib/Frontend/InitPreprocessor.cpp
@@ -1124,7 +1124,8 @@
   if (InitOpts.UsePredefines) {
     // FIXME: This will create multiple definitions for most of the predefined
     // macros. This is not the right way to handle this.
-    if ((LangOpts.CUDA || LangOpts.OpenMPIsDevice) && PP.getAuxTargetInfo())
+    if ((LangOpts.CUDA || LangOpts.OpenMPIsDevice || LangOpts.SYCLIsDevice) &&
+        PP.getAuxTargetInfo())
       InitializePredefinedMacros(*PP.getAuxTargetInfo(), LangOpts, FEOpts,
                                  PP.getPreprocessorOpts(), Builder);
 
diff --git a/clang/test/Frontend/sycl-aux-triple.cpp b/clang/test/Frontend/sycl-aux-triple.cpp
new file mode 100644
--- /dev/null
+++ b/clang/test/Frontend/sycl-aux-triple.cpp
@@ -0,0 +1,5 @@
+// RUN: %clang_cc1 %s -triple spir -aux-triple x86_64-unknown-linux-gnu -E -dM | FileCheck %s
+// RUN: %clang_cc1 %s -fsycl-is-device -triple spir -aux-triple x86_64-unknown-linux-gnu -E -dM | FileCheck --check-prefix=CHECK-SYCL %s
+
+// CHECK-NOT:#define __x86_64__ 1
+// CHECK-SYCL:#define __x86_64__ 1