diff --git a/llvm/lib/Transforms/IPO/HotColdSplitting.cpp b/llvm/lib/Transforms/IPO/HotColdSplitting.cpp
--- a/llvm/lib/Transforms/IPO/HotColdSplitting.cpp
+++ b/llvm/lib/Transforms/IPO/HotColdSplitting.cpp
@@ -129,6 +129,13 @@
 
 /// Check whether it's safe to outline \p BB.
 static bool mayExtractBlock(const BasicBlock &BB) {
+  // Don't extract the indirect destination of a "callbr" instruction as even
+  // though it's ice cold it's not safe to extract it, for reasons similar to
+  // extracting an EH block.
+  for (const auto *pred : predecessors(&BB))
+    if (isa<CallBrInst>(pred->getTerminator()))
+      return false;
+
   // EH pads are unsafe to outline because doing so breaks EH type tables. It
   // follows that invoke instructions cannot be extracted, because CodeExtractor
   // requires unwind destinations to be within the extraction region.
@@ -137,7 +144,7 @@
   // be unreachable. It’s not safe to split them out either.
   auto Term = BB.getTerminator();
   return !BB.hasAddressTaken() && !BB.isEHPad() && !isa<InvokeInst>(Term) &&
-         !isa<ResumeInst>(Term);
+         !isa<ResumeInst>(Term) && !isa<CallBrInst>(Term);
 }
 
 /// Mark \p F cold. Based on this assumption, also optimize it for minimum size.