diff --git a/clang/bindings/python/tests/CMakeLists.txt b/clang/bindings/python/tests/CMakeLists.txt
--- a/clang/bindings/python/tests/CMakeLists.txt
+++ b/clang/bindings/python/tests/CMakeLists.txt
@@ -32,6 +32,11 @@
   set(RUN_PYTHON_TESTS FALSE)
 endif()
 
+# The Python FFI interface is broken on AIX: https://bugs.python.org/issue38628.
+if(${CMAKE_SYSTEM_NAME} MATCHES "AIX")
+  set(RUN_PYTHON_TESTS FALSE)
+endif()
+
 # AArch64, Hexagon, and Sparc have known test failures that need to be
 # addressed.
 # SystemZ has broken Python/FFI interface: