Index: clang/lib/CodeGen/CGCall.cpp
===================================================================
--- clang/lib/CodeGen/CGCall.cpp
+++ clang/lib/CodeGen/CGCall.cpp
@@ -4085,8 +4085,13 @@
         // If the argument doesn't match, perform a bitcast to coerce it.  This
         // can happen due to trivial type mismatches.
         if (FirstIRArg < IRFuncTy->getNumParams() &&
-            V->getType() != IRFuncTy->getParamType(FirstIRArg))
-          V = Builder.CreateBitCast(V, IRFuncTy->getParamType(FirstIRArg));
+            V->getType() != IRFuncTy->getParamType(FirstIRArg)) {
+          if (V->getType()->isPointerTy())
+            V = Builder.CreatePointerBitCastOrAddrSpaceCast(
+                V, IRFuncTy->getParamType(FirstIRArg));
+          else
+            V = Builder.CreateBitCast(V, IRFuncTy->getParamType(FirstIRArg));
+        }
 
         IRCallArgs[FirstIRArg] = V;
         break;
Index: clang/test/CodeGenOpenCLCXX/addrspace-derived-base.cl
===================================================================
--- clang/test/CodeGenOpenCLCXX/addrspace-derived-base.cl
+++ clang/test/CodeGenOpenCLCXX/addrspace-derived-base.cl
@@ -28,6 +28,7 @@
 class B2 {
   public:
     void baseMethod() const {  }
+    int& getRef() { return bb; }
     int bb;
 };
 
@@ -46,7 +47,17 @@
 
 void pr43145_2(B *argB) {
   Derived *x = (Derived*)argB;
+  // CHECK-LABEL: @_Z9pr43145_2
+  // CHECK: bitcast %struct.B addrspace(4)* %0 to %class.Derived addrspace(4)*
 }
 
-// CHECK-LABEL: @_Z9pr43145_2
-// CHECK: bitcast %struct.B addrspace(4)* %0 to %class.Derived addrspace(4)*
+// Assigning to reference returned by base class method through derived class.
+
+void pr43145_3(int n) {
+  Derived d;
+  d.getRef() = n;
+  // CHECK-LABEL: @_Z9pr43145_3
+  // CHECK: bitcast
+  // CHECK: addrspacecast %class.B2* %2 to %class.B2 addrspace(4)*
+  // CHECK: call {{.*}} @_ZNU3AS42B26getRefEv
+}