diff --git a/clang/lib/Sema/SemaExpr.cpp b/clang/lib/Sema/SemaExpr.cpp
--- a/clang/lib/Sema/SemaExpr.cpp
+++ b/clang/lib/Sema/SemaExpr.cpp
@@ -2711,6 +2711,20 @@
       FromRecordType = FromType;
       DestType = DestRecordType;
     }
+
+    LangAS FromAS = FromRecordType.getAddressSpace();
+    LangAS DestAS = DestRecordType.getAddressSpace();
+    if (FromAS != DestAS) {
+      QualType FromRecordTypeWithoutAS =
+          Context.removeAddrSpaceQualType(FromRecordType);
+      QualType FromTypeWithDestAS =
+          Context.getAddrSpaceQualType(FromRecordTypeWithoutAS, DestAS);
+      if (PointerConversions)
+        FromTypeWithDestAS = Context.getPointerType(FromTypeWithDestAS);
+      From = ImpCastExprToType(From, FromTypeWithDestAS,
+                               CK_AddressSpaceConversion, From->getValueKind())
+                 .get();
+    }
   } else {
     // No conversion necessary.
     return From;
diff --git a/clang/test/CodeGenOpenCLCXX/addrspace-derived-base.cl b/clang/test/CodeGenOpenCLCXX/addrspace-derived-base.cl
--- a/clang/test/CodeGenOpenCLCXX/addrspace-derived-base.cl
+++ b/clang/test/CodeGenOpenCLCXX/addrspace-derived-base.cl
@@ -28,6 +28,7 @@
 class B2 {
   public:
     void baseMethod() const {  }
+    int &getRef() { return bb; }
     int bb;
 };
 
@@ -46,7 +47,25 @@
 
 void pr43145_2(B *argB) {
   Derived *x = (Derived*)argB;
+  // CHECK-LABEL: @_Z9pr43145_2
+  // CHECK: bitcast %struct.B addrspace(4)* %0 to %class.Derived addrspace(4)*
 }
 
-// CHECK-LABEL: @_Z9pr43145_2
-// CHECK: bitcast %struct.B addrspace(4)* %0 to %class.Derived addrspace(4)*
+// Assigning to reference returned by base class method through derived class.
+
+void pr43145_3(int n) {
+  Derived d;
+  d.getRef() = n;
+
+  // CHECK-LABEL: @_Z9pr43145_3
+  // CHECK: addrspacecast %class.Derived* %d to %class.Derived addrspace(4)*
+  // CHECK: bitcast i8 addrspace(4)* %add.ptr to %class.B2 addrspace(4)*
+  // CHECK: call {{.*}} @_ZNU3AS42B26getRefEv
+
+  private Derived *pd = &d;
+  pd->getRef() = n;
+
+  // CHECK: addrspacecast %class.Derived* %4 to %class.Derived addrspace(4)*
+  // CHECK: bitcast i8 addrspace(4)* %add.ptr1 to %class.B2 addrspace(4)*
+  // CHECK: call {{.*}} @_ZNU3AS42B26getRefEv
+}