diff --git a/llvm/lib/IR/Function.cpp b/llvm/lib/IR/Function.cpp
--- a/llvm/lib/IR/Function.cpp
+++ b/llvm/lib/IR/Function.cpp
@@ -1533,6 +1533,11 @@
   auto PrevCount = getEntryCount();
   assert(!PrevCount.hasValue() || PrevCount.getType() == Count.getType());
 #endif
+
+  auto ImportGUIDs = getImportGUIDs();
+  if (S == nullptr && ImportGUIDs.size())
+    S = &ImportGUIDs;
+
   MDBuilder MDB(getContext());
   setMetadata(
       LLVMContext::MD_prof,
diff --git a/llvm/lib/Transforms/Utils/InlineFunction.cpp b/llvm/lib/Transforms/Utils/InlineFunction.cpp
--- a/llvm/lib/Transforms/Utils/InlineFunction.cpp
+++ b/llvm/lib/Transforms/Utils/InlineFunction.cpp
@@ -1508,8 +1508,6 @@
   else
     newEntryCount = priorEntryCount + entryDelta;
 
-  Callee->setEntryCount(newEntryCount);
-
   // During inlining ?
   if (VMap) {
     uint64_t cloneEntryCount = priorEntryCount - newEntryCount;
@@ -1518,12 +1516,17 @@
         if (auto *CI = dyn_cast_or_null<CallInst>(Entry.second))
           CI->updateProfWeight(cloneEntryCount, priorEntryCount);
   }
-  for (BasicBlock &BB : *Callee)
-    // No need to update the callsite if it is pruned during inlining.
-    if (!VMap || VMap->count(&BB))
-      for (Instruction &I : BB)
-        if (CallInst *CI = dyn_cast<CallInst>(&I))
-          CI->updateProfWeight(newEntryCount, priorEntryCount);
+
+  if (entryDelta) {
+    Callee->setEntryCount(newEntryCount);
+
+    for (BasicBlock &BB : *Callee)
+      // No need to update the callsite if it is pruned during inlining.
+      if (!VMap || VMap->count(&BB))
+        for (Instruction &I : BB)
+          if (CallInst *CI = dyn_cast<CallInst>(&I))
+            CI->updateProfWeight(newEntryCount, priorEntryCount);
+  }
 }
 
 /// This function inlines the called function into the basic block of the
diff --git a/llvm/test/Transforms/SampleProfile/Inputs/inline-callee-update.prof b/llvm/test/Transforms/SampleProfile/Inputs/inline-callee-update.prof
new file mode 100644
--- /dev/null
+++ b/llvm/test/Transforms/SampleProfile/Inputs/inline-callee-update.prof
@@ -0,0 +1,10 @@
+test_sample_loader_inline:63067:0
+ 1: sample_loader_inlinee:40000
+sample_loader_inlinee:3000:0
+ 1: direct_leaf_func:35000
+  11: 3000
+test_cgscc_inline:63067:0
+ 1: sample_loader_inlinee:1
+cgscc_inlinee:3000:0
+ 1: direct_leaf_func:35000
+  11: 3000
\ No newline at end of file
diff --git a/llvm/test/Transforms/SampleProfile/inline-callee-update.ll b/llvm/test/Transforms/SampleProfile/inline-callee-update.ll
new file mode 100644
--- /dev/null
+++ b/llvm/test/Transforms/SampleProfile/inline-callee-update.ll
@@ -0,0 +1,73 @@
+; Make sure Import GUID list for ThinLTO properly maintained while update function's entry count for inlining
+
+; RUN: opt < %s -passes='thinlto-pre-link<O2>' -pgo-kind=pgo-sample-use-pipeline -sample-profile-file=%S/Inputs/inline-callee-update.prof -S | FileCheck %s
+
+@y = global i32* ()* null, align 8
+@z = global i32* ()* null, align 8
+
+define i32* @sample_loader_inlinee() !dbg !3 {
+bb:
+  %tmp = call i32* @direct_leaf_func(i32* null), !dbg !4
+  %cmp = icmp ne i32* %tmp, null
+  br i1 %cmp, label %then, label %else
+
+then:                                             ; preds = %bb
+  %tmp1 = load i32* ()*, i32* ()** @z, align 8, !dbg !5
+  %tmp2 = call i32* %tmp1(), !dbg !5
+  ret i32* %tmp2
+
+else:                                             ; preds = %bb
+  ret i32* null
+}
+
+define i32* @cgscc_inlinee() !dbg !6 {
+bb:
+  %tmp = call i32* @direct_leaf_func(i32* null), !dbg !7
+  %cmp = icmp ne i32* %tmp, null
+  br i1 %cmp, label %then, label %else
+
+then:                                             ; preds = %bb
+  %tmp1 = load i32* ()*, i32* ()** @y, align 8, !dbg !8
+  %tmp2 = call i32* %tmp1(), !dbg !8
+  ret i32* %tmp2
+
+else:                                             ; preds = %bb
+  ret i32* null
+}
+
+define i32* @test_sample_loader_inline(void ()* %arg) !dbg !9 {
+bb:
+  %tmp = call i32* @sample_loader_inlinee(), !dbg !10
+  ret i32* %tmp
+}
+
+define i32* @test_cgscc_inline(void ()* %arg) !dbg !11 {
+bb:
+  %tmp = call i32* @cgscc_inlinee(), !dbg !12
+  ret i32* %tmp
+}
+
+declare i32* @direct_leaf_func(i32*)
+
+!llvm.dbg.cu = !{!0}
+!llvm.module.flags = !{!2}
+
+!0 = distinct !DICompileUnit(language: DW_LANG_C_plus_plus, file: !1, isOptimized: false, runtimeVersion: 0, emissionKind: NoDebug)
+!1 = !DIFile(filename: "test.cc", directory: "/")
+!2 = !{i32 2, !"Debug Info Version", i32 3}
+!3 = distinct !DISubprogram(name: "sample_loader_inlinee", scope: !1, file: !1, line: 11, spFlags: DISPFlagDefinition, unit: !0)
+!4 = !DILocation(line: 12, scope: !3)
+!5 = !DILocation(line: 13, scope: !3)
+!6 = distinct !DISubprogram(name: "cgscc_inlinee", scope: !1, file: !1, line: 31, spFlags: DISPFlagDefinition, unit: !0)
+!7 = !DILocation(line: 32, scope: !6)
+!8 = !DILocation(line: 33, scope: !6)
+!9 = distinct !DISubprogram(name: "test_sample_loader_inline", scope: !1, file: !1, line: 3, spFlags: DISPFlagDefinition, unit: !0)
+!10 = !DILocation(line: 4, scope: !9)
+!11 = distinct !DISubprogram(name: "test_cgscc_inline", scope: !1, file: !1, line: 20, spFlags: DISPFlagDefinition, unit: !0)
+!12 = !DILocation(line: 21, scope: !11)
+
+; Make sure the ImportGUID stays with entry count metadata for ThinLTO-PreLink
+; CHECK: distinct !DISubprogram(name: "sample_loader_inlinee"
+; CHECK-NEXT: {!"function_entry_count", i64 1, i64 -9171813444624716006}
+; CHECK: distinct !DISubprogram(name: "cgscc_inlinee"
+; CHECK-NEXT: !{!"function_entry_count", i64 0, i64 -9171813444624716006}