Index: clang/include/clang/Basic/DiagnosticSemaKinds.td
===================================================================
--- clang/include/clang/Basic/DiagnosticSemaKinds.td
+++ clang/include/clang/Basic/DiagnosticSemaKinds.td
@@ -2850,6 +2850,8 @@
   "requested alignment is not a power of 2">;
 def err_alignment_dependent_typedef_name : Error<
   "requested alignment is dependent but declaration is not dependent">;
+def warn_assume_align_too_big : Warning<"alignments greater than 1 << 29 are "
+  "unsupported by LLVM">, InGroup<IgnoredAttributes>;
 
 def err_attribute_aligned_too_great : Error<
   "requested alignment must be %0 bytes or smaller">;
Index: clang/lib/CodeGen/CGBuiltin.cpp
===================================================================
--- clang/lib/CodeGen/CGBuiltin.cpp
+++ clang/lib/CodeGen/CGBuiltin.cpp
@@ -2048,11 +2048,10 @@
 
     Value *AlignmentValue = EmitScalarExpr(E->getArg(1));
     ConstantInt *AlignmentCI = cast<ConstantInt>(AlignmentValue);
-    unsigned Alignment = (unsigned)AlignmentCI->getZExtValue();
 
     EmitAlignmentAssumption(PtrValue, Ptr,
                             /*The expr loc is sufficient.*/ SourceLocation(),
-                            Alignment, OffsetValue);
+                            AlignmentCI, OffsetValue);
     return RValue::get(PtrValue);
   }
   case Builtin::BI__assume:
Index: clang/lib/CodeGen/CGCall.cpp
===================================================================
--- clang/lib/CodeGen/CGCall.cpp
+++ clang/lib/CodeGen/CGCall.cpp
@@ -4569,7 +4569,7 @@
       llvm::Value *Alignment = EmitScalarExpr(AA->getAlignment());
       llvm::ConstantInt *AlignmentCI = cast<llvm::ConstantInt>(Alignment);
       EmitAlignmentAssumption(Ret.getScalarVal(), RetTy, Loc, AA->getLocation(),
-                              AlignmentCI->getZExtValue(), OffsetValue);
+                              AlignmentCI, OffsetValue);
     } else if (const auto *AA = TargetDecl->getAttr<AllocAlignAttr>()) {
       llvm::Value *AlignmentVal = CallArgs[AA->getParamIndex().getLLVMIndex()]
                                       .getRValue(*this)
Index: clang/lib/CodeGen/CGExprScalar.cpp
===================================================================
--- clang/lib/CodeGen/CGExprScalar.cpp
+++ clang/lib/CodeGen/CGExprScalar.cpp
@@ -294,8 +294,7 @@
 
     Value *AlignmentValue = CGF.EmitScalarExpr(AVAttr->getAlignment());
     llvm::ConstantInt *AlignmentCI = cast<llvm::ConstantInt>(AlignmentValue);
-    CGF.EmitAlignmentAssumption(V, E, AVAttr->getLocation(),
-                                AlignmentCI->getZExtValue());
+    CGF.EmitAlignmentAssumption(V, E, AVAttr->getLocation(), AlignmentCI);
   }
 
   /// EmitLoadOfLValue - Given an expression with complex type that represents a
Index: clang/lib/CodeGen/CGStmtOpenMP.cpp
===================================================================
--- clang/lib/CodeGen/CGStmtOpenMP.cpp
+++ clang/lib/CodeGen/CGStmtOpenMP.cpp
@@ -1519,14 +1519,14 @@
   if (!CGF.HaveInsertPoint())
     return;
   for (const auto *Clause : D.getClausesOfKind<OMPAlignedClause>()) {
-    unsigned ClauseAlignment = 0;
+    size_t ClauseAlignment = 0;
     if (const Expr *AlignmentExpr = Clause->getAlignment()) {
       auto *AlignmentCI =
           cast<llvm::ConstantInt>(CGF.EmitScalarExpr(AlignmentExpr));
-      ClauseAlignment = static_cast<unsigned>(AlignmentCI->getZExtValue());
+      ClauseAlignment = AlignmentCI->getZExtValue();
     }
     for (const Expr *E : Clause->varlists()) {
-      unsigned Alignment = ClauseAlignment;
+      size_t Alignment = ClauseAlignment;
       if (Alignment == 0) {
         // OpenMP [2.8.1, Description]
         // If no optional parameter is specified, implementation-defined default
@@ -1542,7 +1542,8 @@
       if (Alignment != 0) {
         llvm::Value *PtrValue = CGF.EmitScalarExpr(E);
         CGF.EmitAlignmentAssumption(
-            PtrValue, E, /*No second loc needed*/ SourceLocation(), Alignment);
+            PtrValue, E, /*No second loc needed*/ SourceLocation(),
+            llvm::ConstantInt::get(CGF.SizeTy, Alignment));
       }
     }
   }
Index: clang/lib/CodeGen/CodeGenFunction.h
===================================================================
--- clang/lib/CodeGen/CodeGenFunction.h
+++ clang/lib/CodeGen/CodeGenFunction.h
@@ -2828,14 +2828,14 @@
                                SourceLocation Loc, SourceLocation AssumptionLoc,
                                llvm::Value *Alignment,
                                llvm::Value *OffsetValue = nullptr);
-
+/*
   void EmitAlignmentAssumption(llvm::Value *PtrValue, QualType Ty,
                                SourceLocation Loc, SourceLocation AssumptionLoc,
                                unsigned Alignment,
                                llvm::Value *OffsetValue = nullptr);
-
+*/
   void EmitAlignmentAssumption(llvm::Value *PtrValue, const Expr *E,
-                               SourceLocation AssumptionLoc, unsigned Alignment,
+                               SourceLocation AssumptionLoc, llvm::Value *Alignment,
                                llvm::Value *OffsetValue = nullptr);
 
   //===--------------------------------------------------------------------===//
Index: clang/lib/CodeGen/CodeGenFunction.cpp
===================================================================
--- clang/lib/CodeGen/CodeGenFunction.cpp
+++ clang/lib/CodeGen/CodeGenFunction.cpp
@@ -2055,7 +2055,7 @@
                                  OffsetValue, TheCheck, Assumption);
   }
 }
-
+/*
 void CodeGenFunction::EmitAlignmentAssumption(llvm::Value *PtrValue,
                                               QualType Ty, SourceLocation Loc,
                                               SourceLocation AssumptionLoc,
@@ -2070,11 +2070,11 @@
                                  OffsetValue, TheCheck, Assumption);
   }
 }
-
+*/
 void CodeGenFunction::EmitAlignmentAssumption(llvm::Value *PtrValue,
                                               const Expr *E,
                                               SourceLocation AssumptionLoc,
-                                              unsigned Alignment,
+                                              llvm::Value *Alignment,
                                               llvm::Value *OffsetValue) {
   if (auto *CE = dyn_cast<CastExpr>(E))
     E = CE->getSubExprAsWritten();
Index: clang/lib/Sema/SemaChecking.cpp
===================================================================
--- clang/lib/Sema/SemaChecking.cpp
+++ clang/lib/Sema/SemaChecking.cpp
@@ -6063,6 +6063,9 @@
     if (!Result.isPowerOf2())
       return Diag(TheCall->getBeginLoc(), diag::err_alignment_not_power_of_two)
              << Arg->getSourceRange();
+    if (Result > (1 << 29ULL))
+      Diag(TheCall->getBeginLoc(), diag::warn_assume_align_too_big)
+             << Arg->getSourceRange();
   }
 
   if (NumArgs > 2) {
Index: clang/test/Sema/builtin-assume-aligned.c
===================================================================
--- clang/test/Sema/builtin-assume-aligned.c
+++ clang/test/Sema/builtin-assume-aligned.c
@@ -58,3 +58,7 @@
 void *test_no_fn_proto() __attribute__((assume_aligned())); // expected-error {{'assume_aligned' attribute takes at least 1 argument}}
 void *test_no_fn_proto() __attribute__((assume_aligned(32, 45, 37))); // expected-error {{'assume_aligned' attribute takes no more than 2 arguments}}
 
+int pr43638(int *a) {
+  a = __builtin_assume_aligned(a, 4294967296); // expected-warning {{alignments greater than 1 << 29 are unsupported by LLVM}}
+  return a[0];
+}