diff --git a/compiler-rt/lib/hwasan/hwasan.h b/compiler-rt/lib/hwasan/hwasan.h
--- a/compiler-rt/lib/hwasan/hwasan.h
+++ b/compiler-rt/lib/hwasan/hwasan.h
@@ -74,6 +74,7 @@
 
 bool ProtectRange(uptr beg, uptr end);
 bool InitShadow();
+void InitPrctl();
 void InitThreads();
 void MadviseShadow();
 char *GetProcSelfMaps();
diff --git a/compiler-rt/lib/hwasan/hwasan.cpp b/compiler-rt/lib/hwasan/hwasan.cpp
--- a/compiler-rt/lib/hwasan/hwasan.cpp
+++ b/compiler-rt/lib/hwasan/hwasan.cpp
@@ -312,6 +312,8 @@
 static void InitInstrumentation() {
   if (hwasan_instrumentation_inited) return;
 
+  InitPrctl();
+
   if (!InitShadow()) {
     Printf("FATAL: HWAddressSanitizer cannot mmap the shadow memory.\n");
     DumpProcessMap();
diff --git a/compiler-rt/lib/hwasan/hwasan_linux.cpp b/compiler-rt/lib/hwasan/hwasan_linux.cpp
--- a/compiler-rt/lib/hwasan/hwasan_linux.cpp
+++ b/compiler-rt/lib/hwasan/hwasan_linux.cpp
@@ -34,6 +34,8 @@
 #include <sys/time.h>
 #include <unistd.h>
 #include <unwind.h>
+#include <sys/prctl.h>
+#include <errno.h>
 
 #include "sanitizer_common/sanitizer_common.h"
 #include "sanitizer_common/sanitizer_procmaps.h"
@@ -144,6 +146,42 @@
       FindDynamicShadowStart(shadow_size_bytes);
 }
 
+void InitPrctl() {
+#define PR_SET_TAGGED_ADDR_CTRL        55
+#define PR_GET_TAGGED_ADDR_CTRL        56
+#define PR_TAGGED_ADDR_ENABLE  (1UL << 0)
+
+  // Check we're running on a kernel that can use the tagged address ABI.
+  if (internal_prctl(PR_GET_TAGGED_ADDR_CTRL, 0, 0, 0, 0) == -1
+      && errno == EINVAL) {
+#if SANITIZER_ANDROID
+    // Some older Android kernels have the tagged pointer ABI on
+    // unconditionally, and hence don't have the tagged-addr prctl while still
+    // allow the ABI.
+    // If targeting Android and the prctl is not around we assume this is the
+    // case.
+    return;
+#else
+    Printf("FATAL: "
+           "HWAddressSanitizer requires a kernel with tagged address ABI.\n");
+    Die();
+#endif
+  }
+
+  // Turn on the tagged address ABI.
+  if (internal_prctl(PR_SET_TAGGED_ADDR_CTRL,
+                     PR_TAGGED_ADDR_ENABLE, 0, 0, 0) == -1
+      || ! internal_prctl(PR_GET_TAGGED_ADDR_CTRL, 0, 0, 0, 0)) {
+    Printf("FATAL: HWAddressSanitizer failed to enable tagged address "
+           "syscall ABI.\n"
+           "Suggest check `sysctl abi.tagged_addr_disabled` configuration.\n");
+    Die();
+  }
+#undef PR_SET_TAGGED_ADDR_CTRL
+#undef PR_GET_TAGGED_ADDR_CTRL
+#undef PR_TAGGED_ADDR_ENABLE
+}
+
 bool InitShadow() {
   // Define the entire memory range.
   kHighMemEnd = GetHighMemEnd();