diff --git a/llvm/lib/Transforms/Instrumentation/AddressSanitizer.cpp b/llvm/lib/Transforms/Instrumentation/AddressSanitizer.cpp
--- a/llvm/lib/Transforms/Instrumentation/AddressSanitizer.cpp
+++ b/llvm/lib/Transforms/Instrumentation/AddressSanitizer.cpp
@@ -1808,6 +1808,8 @@
   if (GlobalsMD.get(G).IsBlacklisted) return false;
   if (!Ty->isSized()) return false;
   if (!G->hasInitializer()) return false;
+  // Only instrument globals of default address spaces
+  if (G->getAddressSpace()) return false;
   if (GlobalWasGeneratedByCompiler(G)) return false; // Our own globals.
   // Two problems with thread-locals:
   //   - The address of the main thread's copy can't be computed at link-time.
diff --git a/llvm/test/Instrumentation/AddressSanitizer/global_addrspace.ll b/llvm/test/Instrumentation/AddressSanitizer/global_addrspace.ll
new file mode 100644
--- /dev/null
+++ b/llvm/test/Instrumentation/AddressSanitizer/global_addrspace.ll
@@ -0,0 +1,31 @@
+; Only verify that asan don't crash on global variables of different
+; address space. The global variable should be unmodified by asan.
+
+; RUN: opt < %s -asan -asan-module -S | FileCheck %s
+
+target datalayout = "e-m:e-p270:32:32-p271:32:32-p272:64:64-i64:64-f80:128-n8:16:32:64-S128"
+target triple = "x86_64-unknown-linux-gnu"
+
+@a = internal addrspace(42) global [1 x i32] zeroinitializer, align 4
+
+; CHECK: @a = internal addrspace(42) global [1 x i32] zeroinitializer, align 4
+
+define void @b(i32 %c) {
+entry:
+  %conv = sext i32 %c to i64
+  %0 = inttoptr i64 %conv to i32 addrspace(42)*
+  %cmp = icmp ugt i32 addrspace(42)* %0, getelementptr inbounds ([1 x i32], [1 x i32] addrspace(42)* @a, i64 0, i64 0)
+  br i1 %cmp, label %if.then, label %if.end
+
+if.then:
+  %call = tail call i32 (...) @e()
+  br label %if.end
+
+if.end:
+  ret void
+}
+
+declare i32 @e(...)
+
+!llvm.asan.globals = !{!0}
+!0 = !{[1 x i32] addrspace(42)* @a, null, !"a", i1 false, i1 false}