diff --git a/llvm/utils/update_cc_test_checks.py b/llvm/utils/update_cc_test_checks.py
--- a/llvm/utils/update_cc_test_checks.py
+++ b/llvm/utils/update_cc_test_checks.py
@@ -112,10 +112,17 @@
   return args
 
 
-def get_function_body(args, filename, clang_args, prefixes, triple_in_cmd, func_dict):
+def get_function_body(args, filename, clang_args, extra_commands, prefixes, triple_in_cmd, func_dict):
   # TODO Clean up duplication of asm/common build_function_body_dictionary
   # Invoke external tool and extract function bodies.
   raw_tool_output = common.invoke_tool(args.clang, clang_args, filename)
+  for extra_command in extra_commands:
+    extra_args = shlex.split(extra_command)
+    with tempfile.NamedTemporaryFile() as f:
+      f.write(raw_tool_output.encode())
+      f.flush()
+      raw_tool_output = common.invoke_tool(extra_args[0],
+                                           extra_args[1:], f.name)
   if '-emit-llvm' in clang_args:
     common.build_function_body_dictionary(
             common.OPT_FUNCTION_RE, common.scrub_body, [],
@@ -164,7 +171,7 @@
     run_list = []
     line2spell_and_mangled_list = collections.defaultdict(list)
     for l in run_lines:
-      commands = [cmd.strip() for cmd in l.split('|', 1)]
+      commands = [cmd.strip() for cmd in l.split('|')]
 
       triple_in_cmd = None
       m = common.TRIPLE_ARG_RE.search(commands[0])
@@ -179,6 +186,11 @@
       clang_args[0:1] = SUBST[clang_args[0]]
       clang_args = [filename if i == '%s' else i for i in clang_args] + args.clang_args
 
+      # Permit piping the output through opt
+      if not (len(commands) == 2 or
+              (len(commands) == 3 and commands[1].startswith("opt"))):
+        print('WARNING: Skipping non-clang RUN line: ' + l, file=sys.stderr)
+
       # Extract -check-prefix in FileCheck args
       filecheck_cmd = commands[-1]
       common.verify_filecheck_prefixes(filecheck_cmd)
@@ -189,7 +201,7 @@
                                for item in m.group(1).split(',')]
       if not check_prefixes:
         check_prefixes = ['CHECK']
-      run_list.append((check_prefixes, clang_args, triple_in_cmd))
+      run_list.append((check_prefixes, clang_args, commands[1:-1], triple_in_cmd))
 
     # Strip CHECK lines which are in `prefix_set`, update test file.
     prefix_set = set([prefix for p in run_list for prefix in p[0]])
@@ -209,12 +221,12 @@
       prefixes = p[0]
       for prefix in prefixes:
         func_dict.update({prefix: dict()})
-    for prefixes, clang_args, triple_in_cmd in run_list:
+    for prefixes, clang_args, extra_commands, triple_in_cmd in run_list:
       if args.verbose:
         print('Extracted clang cmd: clang {}'.format(clang_args), file=sys.stderr)
         print('Extracted FileCheck prefixes: {}'.format(prefixes), file=sys.stderr)
 
-      get_function_body(args, filename, clang_args, prefixes, triple_in_cmd, func_dict)
+      get_function_body(args, filename, clang_args, extra_commands, prefixes, triple_in_cmd, func_dict)
 
       # Invoke c-index-test to get mapping from start lines to mangled names.
       # Forward all clang args for now.