diff --git a/clang/lib/CodeGen/CGClass.cpp b/clang/lib/CodeGen/CGClass.cpp
--- a/clang/lib/CodeGen/CGClass.cpp
+++ b/clang/lib/CodeGen/CGClass.cpp
@@ -246,7 +246,8 @@
 
   // Apply the base offset.
   llvm::Value *ptr = addr.getPointer();
-  ptr = CGF.Builder.CreateBitCast(ptr, CGF.Int8PtrTy);
+  unsigned AddrSpace = ptr->getType()->getPointerAddressSpace();
+  ptr = CGF.Builder.CreateBitCast(ptr, CGF.Int8Ty->getPointerTo(AddrSpace));
   ptr = CGF.Builder.CreateInBoundsGEP(ptr, baseOffset, "add.ptr");
 
   // If we have a virtual component, the alignment of the result will
@@ -381,7 +382,9 @@
 
   QualType DerivedTy =
     getContext().getCanonicalType(getContext().getTagDeclType(Derived));
-  llvm::Type *DerivedPtrTy = ConvertType(DerivedTy)->getPointerTo();
+  unsigned AddrSpace =
+    BaseAddr.getPointer()->getType()->getPointerAddressSpace();
+  llvm::Type *DerivedPtrTy = ConvertType(DerivedTy)->getPointerTo(AddrSpace);
 
   llvm::Value *NonVirtualOffset =
     CGM.GetNonVirtualBaseClassOffset(Derived, PathBegin, PathEnd);
diff --git a/clang/test/CodeGenOpenCLCXX/addrspace-derived-base.cl b/clang/test/CodeGenOpenCLCXX/addrspace-derived-base.cl
--- a/clang/test/CodeGenOpenCLCXX/addrspace-derived-base.cl
+++ b/clang/test/CodeGenOpenCLCXX/addrspace-derived-base.cl
@@ -11,6 +11,7 @@
 
 void foo() {
   D d;
+  //CHECK-LABEL: foo
   //CHECK: addrspacecast %class.D* %d to %class.D addrspace(4)*
   //CHECK: call spir_func i32 @_ZNU3AS41D5getmbEv(%class.D addrspace(4)*
   d.getmb();
@@ -20,3 +21,32 @@
 
 //CHECK: define linkonce_odr spir_func i32 @_ZNU3AS41D5getmbEv(%class.D addrspace(4)* %this)
 //CHECK: bitcast %class.D addrspace(4)* %this1 to %struct.B addrspace(4)*
+
+
+// Calling base method through multiple inheritance.
+
+class B2 {
+  public:
+    void baseMethod() const {  }
+    int bb;
+};
+
+class Derived : public B, public B2 {
+  public:
+    void work() const { baseMethod(); }
+    // CHECK-LABEL: work
+    // CHECK: bitcast i8 addrspace(4)* %add.ptr to %class.B2 addrspace(4)*
+};
+
+void pr43145(const Derived *argDerived) {
+  argDerived->work();
+}
+
+// Casting from base to derived.
+
+void pr43145_2(B *argB) {
+  Derived *x = (Derived*)argB;
+}
+
+// CHECK-LABEL: @_Z9pr43145_2
+// CHECK: bitcast %struct.B addrspace(4)* %0 to %class.Derived addrspace(4)*