diff --git a/clang/lib/Lex/DependencyDirectivesSourceMinimizer.cpp b/clang/lib/Lex/DependencyDirectivesSourceMinimizer.cpp
--- a/clang/lib/Lex/DependencyDirectivesSourceMinimizer.cpp
+++ b/clang/lib/Lex/DependencyDirectivesSourceMinimizer.cpp
@@ -244,14 +244,20 @@
   }
 }
 
-static const char *reverseOverSpaces(const char *First, const char *Last) {
+static const char *findLastNonSpace(const char *First, const char *Last) {
   assert(First <= Last);
-  const char *PrevLast = Last;
-  while (First != Last && isHorizontalWhitespace(Last[-1])) {
-    PrevLast = Last;
+  while (First != Last && isHorizontalWhitespace(Last[-1]))
     --Last;
-  }
-  return PrevLast;
+  return Last;
+}
+
+static const char *findFirstTrailingSpace(const char *First,
+                                          const char *Last) {
+  const char *LastNonSpace = findLastNonSpace(First, Last);
+  if (Last == LastNonSpace)
+    return Last;
+  assert(isHorizontalWhitespace(LastNonSpace[0]));
+  return LastNonSpace + 1;
 }
 
 static void skipLineComment(const char *&First, const char *const End) {
@@ -385,7 +391,7 @@
       }
 
       // Deal with "//..." and "/*...*/".
-      append(First, reverseOverSpaces(First, Last));
+      append(First, findFirstTrailingSpace(First, Last));
       First = Last;
 
       if (Last[1] == '/') {
@@ -400,15 +406,20 @@
     } while (Last != End && !isVerticalWhitespace(*Last));
 
     // Print out the string.
-    if (Last == End || Last == First || Last[-1] != '\\') {
-      append(First, reverseOverSpaces(First, Last));
+    const char *LastBeforeTrailingSpace = findLastNonSpace(First, Last);
+    if (Last == End || LastBeforeTrailingSpace == First ||
+        LastBeforeTrailingSpace[-1] != '\\') {
+      append(First, LastBeforeTrailingSpace);
       First = Last;
       skipNewline(First, End);
       return;
     }
 
-    // Print up to the backslash, backing up over spaces.
-    append(First, reverseOverSpaces(First, Last - 1));
+    // Print up to the backslash, backing up over spaces. Preserve at least one
+    // space, as the space matters when tokens are separated by a line
+    // continuation.
+    append(First, findFirstTrailingSpace(
+                      First, LastBeforeTrailingSpace - 1));
 
     First = Last;
     skipNewline(First, End);
diff --git a/clang/unittests/Lex/DependencyDirectivesSourceMinimizerTest.cpp b/clang/unittests/Lex/DependencyDirectivesSourceMinimizerTest.cpp
--- a/clang/unittests/Lex/DependencyDirectivesSourceMinimizerTest.cpp
+++ b/clang/unittests/Lex/DependencyDirectivesSourceMinimizerTest.cpp
@@ -157,19 +157,19 @@
 
   ASSERT_FALSE(minimizeSourceToDependencyDirectives(
       "#define MACRO(\t)\tcon \t tent\t", Out));
-  EXPECT_STREQ("#define MACRO() con \t tent\t\n", Out.data());
+  EXPECT_STREQ("#define MACRO() con \t tent\n", Out.data());
 
   ASSERT_FALSE(minimizeSourceToDependencyDirectives(
       "#define MACRO(\f)\fcon \f tent\f", Out));
-  EXPECT_STREQ("#define MACRO() con \f tent\f\n", Out.data());
+  EXPECT_STREQ("#define MACRO() con \f tent\n", Out.data());
 
   ASSERT_FALSE(minimizeSourceToDependencyDirectives(
       "#define MACRO(\v)\vcon \v tent\v", Out));
-  EXPECT_STREQ("#define MACRO() con \v tent\v\n", Out.data());
+  EXPECT_STREQ("#define MACRO() con \v tent\n", Out.data());
 
   ASSERT_FALSE(minimizeSourceToDependencyDirectives(
       "#define MACRO \t\v\f\v\t con\f\t\vtent\v\f \v", Out));
-  EXPECT_STREQ("#define MACRO con\f\t\vtent\v\n", Out.data());
+  EXPECT_STREQ("#define MACRO con\f\t\vtent\n", Out.data());
 }
 
 TEST(MinimizeSourceToDependencyDirectivesTest, DefineMultilineArgs) {
@@ -476,6 +476,17 @@
   EXPECT_STREQ("#define GUA RD\n", Out.data());
 }
 
+TEST(MinimizeSourceToDependencyDirectivesTest,
+     WhitespaceAfterLineContinuationSlash) {
+  SmallVector<char, 128> Out;
+
+  ASSERT_FALSE(minimizeSourceToDependencyDirectives("#define A 1 + \\  \n"
+                                                    "2 + \\\t\n"
+                                                    "3\n",
+                                                    Out));
+  EXPECT_STREQ("#define A 1 + 2 + 3\n", Out.data());
+}
+
 TEST(MinimizeSourceToDependencyDirectivesTest, PoundWarningAndError) {
   SmallVector<char, 128> Out;