diff --git a/llvm/lib/Analysis/InstructionSimplify.cpp b/llvm/lib/Analysis/InstructionSimplify.cpp
--- a/llvm/lib/Analysis/InstructionSimplify.cpp
+++ b/llvm/lib/Analysis/InstructionSimplify.cpp
@@ -1372,7 +1372,7 @@
 /// with the parameters swapped.
 static Value *simplifyUnsignedRangeCheck(ICmpInst *ZeroICmp,
                                          ICmpInst *UnsignedICmp, bool IsAnd,
-                                         const DataLayout &DL) {
+                                         const SimplifyQuery &Q) {
   Value *X, *Y;
 
   ICmpInst::Predicate EqPred;
@@ -1381,6 +1381,26 @@
     return nullptr;
 
   ICmpInst::Predicate UnsignedPred;
+
+  // Y = (A - B);  Y >= A && Y != 0  --> Y >= A  iff B != 0
+  // Y = (A - B);  Y <  A || Y == 0  --> Y <  A  iff B != 0
+  Value *A, *B;
+  if (match(Y, m_Sub(m_Value(A), m_Value(B))) &&
+      match(UnsignedICmp,
+            m_c_ICmp(UnsignedPred, m_Specific(Y), m_Specific(A)))) {
+    if (UnsignedICmp->getOperand(0) != Y)
+      UnsignedPred = ICmpInst::getSwappedPredicate(UnsignedPred);
+
+    if (UnsignedPred == ICmpInst::ICMP_UGE && IsAnd &&
+        EqPred == ICmpInst::ICMP_NE &&
+        isKnownNonZero(B, Q.DL, /*Depth=*/0, Q.AC, Q.CxtI, Q.DT))
+      return UnsignedICmp;
+    if (UnsignedPred == ICmpInst::ICMP_ULT && !IsAnd &&
+        EqPred == ICmpInst::ICMP_EQ &&
+        isKnownNonZero(B, Q.DL, /*Depth=*/0, Q.AC, Q.CxtI, Q.DT))
+      return UnsignedICmp;
+  }
+
   if (match(UnsignedICmp, m_ICmp(UnsignedPred, m_Value(X), m_Specific(Y))) &&
       ICmpInst::isUnsigned(UnsignedPred))
     ;
@@ -1399,13 +1419,13 @@
   // X <= Y && Y != 0  -->  X <= Y  iff X != 0
   // X <= Y || Y != 0  -->  Y != 0  iff X != 0
   if (UnsignedPred == ICmpInst::ICMP_ULE && EqPred == ICmpInst::ICMP_NE &&
-      isKnownNonZero(X, DL))
+      isKnownNonZero(X, Q.DL, /*Depth=*/0, Q.AC, Q.CxtI, Q.DT))
     return IsAnd ? UnsignedICmp : ZeroICmp;
 
   // X > Y && Y == 0  -->  Y == 0  iff X != 0
   // X > Y || Y == 0  -->  X > Y   iff X != 0
   if (UnsignedPred == ICmpInst::ICMP_UGT && EqPred == ICmpInst::ICMP_EQ &&
-      isKnownNonZero(X, DL))
+      isKnownNonZero(X, Q.DL, /*Depth=*/0, Q.AC, Q.CxtI, Q.DT))
     return IsAnd ? ZeroICmp : UnsignedICmp;
 
   // X >= Y || Y != 0  -->  true
@@ -1600,11 +1620,10 @@
 }
 
 static Value *simplifyAndOfICmps(ICmpInst *Op0, ICmpInst *Op1,
-                                 const InstrInfoQuery &IIQ,
-                                 const DataLayout &DL) {
-  if (Value *X = simplifyUnsignedRangeCheck(Op0, Op1, /*IsAnd=*/true, DL))
+                                 const SimplifyQuery &Q) {
+  if (Value *X = simplifyUnsignedRangeCheck(Op0, Op1, /*IsAnd=*/true, Q))
     return X;
-  if (Value *X = simplifyUnsignedRangeCheck(Op1, Op0, /*IsAnd=*/true, DL))
+  if (Value *X = simplifyUnsignedRangeCheck(Op1, Op0, /*IsAnd=*/true, Q))
     return X;
 
   if (Value *X = simplifyAndOfICmpsWithSameOperands(Op0, Op1))
@@ -1618,9 +1637,9 @@
   if (Value *X = simplifyAndOrOfICmpsWithZero(Op0, Op1, true))
     return X;
 
-  if (Value *X = simplifyAndOfICmpsWithAdd(Op0, Op1, IIQ))
+  if (Value *X = simplifyAndOfICmpsWithAdd(Op0, Op1, Q.IIQ))
     return X;
-  if (Value *X = simplifyAndOfICmpsWithAdd(Op1, Op0, IIQ))
+  if (Value *X = simplifyAndOfICmpsWithAdd(Op1, Op0, Q.IIQ))
     return X;
 
   return nullptr;
@@ -1674,11 +1693,10 @@
 }
 
 static Value *simplifyOrOfICmps(ICmpInst *Op0, ICmpInst *Op1,
-                                const InstrInfoQuery &IIQ,
-                                const DataLayout &DL) {
-  if (Value *X = simplifyUnsignedRangeCheck(Op0, Op1, /*IsAnd=*/false, DL))
+                                const SimplifyQuery &Q) {
+  if (Value *X = simplifyUnsignedRangeCheck(Op0, Op1, /*IsAnd=*/false, Q))
     return X;
-  if (Value *X = simplifyUnsignedRangeCheck(Op1, Op0, /*IsAnd=*/false, DL))
+  if (Value *X = simplifyUnsignedRangeCheck(Op1, Op0, /*IsAnd=*/false, Q))
     return X;
 
   if (Value *X = simplifyOrOfICmpsWithSameOperands(Op0, Op1))
@@ -1692,9 +1710,9 @@
   if (Value *X = simplifyAndOrOfICmpsWithZero(Op0, Op1, false))
     return X;
 
-  if (Value *X = simplifyOrOfICmpsWithAdd(Op0, Op1, IIQ))
+  if (Value *X = simplifyOrOfICmpsWithAdd(Op0, Op1, Q.IIQ))
     return X;
-  if (Value *X = simplifyOrOfICmpsWithAdd(Op1, Op0, IIQ))
+  if (Value *X = simplifyOrOfICmpsWithAdd(Op1, Op0, Q.IIQ))
     return X;
 
   return nullptr;
@@ -1753,8 +1771,8 @@
   auto *ICmp0 = dyn_cast<ICmpInst>(Op0);
   auto *ICmp1 = dyn_cast<ICmpInst>(Op1);
   if (ICmp0 && ICmp1)
-    V = IsAnd ? simplifyAndOfICmps(ICmp0, ICmp1, Q.IIQ, Q.DL)
-              : simplifyOrOfICmps(ICmp0, ICmp1, Q.IIQ, Q.DL);
+    V = IsAnd ? simplifyAndOfICmps(ICmp0, ICmp1, Q)
+              : simplifyOrOfICmps(ICmp0, ICmp1, Q);
 
   auto *FCmp0 = dyn_cast<FCmpInst>(Op0);
   auto *FCmp1 = dyn_cast<FCmpInst>(Op1);
diff --git a/llvm/test/Transforms/InstSimplify/result-of-usub-by-nonzero-is-non-zero-and-no-overflow.ll b/llvm/test/Transforms/InstSimplify/result-of-usub-by-nonzero-is-non-zero-and-no-overflow.ll
--- a/llvm/test/Transforms/InstSimplify/result-of-usub-by-nonzero-is-non-zero-and-no-overflow.ll
+++ b/llvm/test/Transforms/InstSimplify/result-of-usub-by-nonzero-is-non-zero-and-no-overflow.ll
@@ -10,9 +10,7 @@
 ; CHECK-NEXT:    [[OFFSET:%.*]] = ptrtoint i64* [[OFFSETPTR:%.*]] to i64
 ; CHECK-NEXT:    [[ADJUSTED:%.*]] = sub i64 [[BASE:%.*]], [[OFFSET]]
 ; CHECK-NEXT:    [[NO_UNDERFLOW:%.*]] = icmp uge i64 [[ADJUSTED]], [[BASE]]
-; CHECK-NEXT:    [[NOT_NULL:%.*]] = icmp ne i64 [[ADJUSTED]], 0
-; CHECK-NEXT:    [[R:%.*]] = and i1 [[NOT_NULL]], [[NO_UNDERFLOW]]
-; CHECK-NEXT:    ret i1 [[R]]
+; CHECK-NEXT:    ret i1 [[NO_UNDERFLOW]]
 ;
   %offset = ptrtoint i64* %offsetptr to i64
 
@@ -28,9 +26,7 @@
 ; CHECK-NEXT:    [[OFFSET:%.*]] = ptrtoint i64* [[OFFSETPTR:%.*]] to i64
 ; CHECK-NEXT:    [[ADJUSTED:%.*]] = sub i64 [[BASE:%.*]], [[OFFSET]]
 ; CHECK-NEXT:    [[NO_UNDERFLOW:%.*]] = icmp ult i64 [[ADJUSTED]], [[BASE]]
-; CHECK-NEXT:    [[NOT_NULL:%.*]] = icmp eq i64 [[ADJUSTED]], 0
-; CHECK-NEXT:    [[R:%.*]] = or i1 [[NOT_NULL]], [[NO_UNDERFLOW]]
-; CHECK-NEXT:    ret i1 [[R]]
+; CHECK-NEXT:    ret i1 [[NO_UNDERFLOW]]
 ;
   %offset = ptrtoint i64* %offsetptr to i64
 
@@ -46,9 +42,7 @@
 ; CHECK-NEXT:    [[OFFSET:%.*]] = ptrtoint i64* [[OFFSETPTR:%.*]] to i64
 ; CHECK-NEXT:    [[ADJUSTED:%.*]] = sub i64 [[BASE:%.*]], [[OFFSET]]
 ; CHECK-NEXT:    [[NO_UNDERFLOW:%.*]] = icmp ule i64 [[BASE]], [[ADJUSTED]]
-; CHECK-NEXT:    [[NOT_NULL:%.*]] = icmp ne i64 [[ADJUSTED]], 0
-; CHECK-NEXT:    [[R:%.*]] = and i1 [[NOT_NULL]], [[NO_UNDERFLOW]]
-; CHECK-NEXT:    ret i1 [[R]]
+; CHECK-NEXT:    ret i1 [[NO_UNDERFLOW]]
 ;
   %offset = ptrtoint i64* %offsetptr to i64
 
@@ -64,9 +58,7 @@
 ; CHECK-NEXT:    [[OFFSET:%.*]] = ptrtoint i64* [[OFFSETPTR:%.*]] to i64
 ; CHECK-NEXT:    [[ADJUSTED:%.*]] = sub i64 [[BASE:%.*]], [[OFFSET]]
 ; CHECK-NEXT:    [[NO_UNDERFLOW:%.*]] = icmp ugt i64 [[BASE]], [[ADJUSTED]]
-; CHECK-NEXT:    [[NOT_NULL:%.*]] = icmp eq i64 [[ADJUSTED]], 0
-; CHECK-NEXT:    [[R:%.*]] = or i1 [[NOT_NULL]], [[NO_UNDERFLOW]]
-; CHECK-NEXT:    ret i1 [[R]]
+; CHECK-NEXT:    ret i1 [[NO_UNDERFLOW]]
 ;
   %offset = ptrtoint i64* %offsetptr to i64