Index: packages/Python/lldbsuite/test/driver/batch_mode/TestBatchMode.py
===================================================================
--- packages/Python/lldbsuite/test/driver/batch_mode/TestBatchMode.py
+++ packages/Python/lldbsuite/test/driver/batch_mode/TestBatchMode.py
@@ -24,11 +24,9 @@
         self.build()
 
         exe = self.getBuildArtifact("a.out")
-        module_cache = self.getBuildArtifact("module.cache")
 
         # Pass CRASH so the process will crash and stop in batch mode.
         extra_args = ['-b',
-            '-o', "settings set symbols.clang-modules-cache-path '%s'"%module_cache,
             '-o', 'break set -n main',
             '-o', 'run',
             '-o', 'continue',
@@ -57,11 +55,9 @@
         self.build()
 
         exe = self.getBuildArtifact("a.out")
-        module_cache = self.getBuildArtifact("module.cache")
 
         # Now do it again, and make sure if we don't crash, we quit:
         extra_args = ['-b',
-            '-o', "settings set symbols.clang-modules-cache-path '%s'"%module_cache,
             '-o', 'break set -n main',
             '-o', 'run',
             '-o', 'continue',
@@ -96,7 +92,6 @@
         self.setTearDownCleanup()
 
         exe = self.getBuildArtifact("a.out")
-        module_cache = self.getBuildArtifact("module.cache")
 
         # Start up the process by hand, attach to it, and wait for its completion.
         # Attach is funny, since it looks like it stops with a signal on most Unixen so
@@ -117,7 +112,6 @@
 
         extra_args = [
             '-b',
-            '-o', "settings set symbols.clang-modules-cache-path '%s'"%module_cache,
             '-o', 'process attach -p %d'%victim_pid,
             '-o', "breakpoint set --file '%s' -p 'Stop here to unset keep_waiting' -N keep_waiting"%self.source,
             '-o', 'continue',
Index: packages/Python/lldbsuite/test/lldbtest.py
===================================================================
--- packages/Python/lldbsuite/test/lldbtest.py
+++ packages/Python/lldbsuite/test/lldbtest.py
@@ -684,16 +684,31 @@
         """Return absolute path to a file in the test's source directory."""
         return os.path.join(self.getSourceDir(), name)
 
-    @staticmethod
-    def setUpCommands():
-        return [
+    @classmethod
+    def setUpCommands(cls):
+        commands = [
             # Disable Spotlight lookup. The testsuite creates
             # different binaries with the same UUID, because they only
             # differ in the debug info, which is not being hashed.
             "settings set symbols.enable-external-lookup false",
 
             # Testsuite runs in parallel and the host can have also other load.
-            "settings set plugin.process.gdb-remote.packet-timeout 60"]
+            "settings set plugin.process.gdb-remote.packet-timeout 60",
+
+            'settings set symbols.clang-modules-cache-path "{}"'.format(
+                configuration.module_cache_dir),
+            "settings set use-color false",
+        ]
+        # Make sure that a sanitizer LLDB's environment doesn't get passed on.
+        if cls.platformContext and cls.platformContext.shlib_environment_var in os.environ:
+            commands.append('settings set target.env-vars {}='
+                    .format(cls.platformContext.shlib_environment_var))
+
+        # Set environment variables for the inferior.
+        if lldbtest_config.inferior_env:
+            commands.append('settings set target.env-vars ' +
+                    lldbtest_config.inferior_env)
+        return commands
 
     def setUp(self):
         """Fixture for unittest test case setup.
@@ -1851,25 +1866,9 @@
         # decorators.
         Base.setUp(self)
 
-        # Set the clang modules cache path used by LLDB.
-        self.runCmd(
-            'settings set symbols.clang-modules-cache-path "{}"'.format(
-                configuration.module_cache_dir))
-
         for s in self.setUpCommands():
             self.runCmd(s)
 
-        # Disable color.
-        self.runCmd("settings set use-color false")
-
-        # Make sure that a sanitizer LLDB's environment doesn't get passed on.
-        if 'DYLD_LIBRARY_PATH' in os.environ:
-            self.runCmd('settings set target.env-vars DYLD_LIBRARY_PATH=')
-
-        # Set environment variables for the inferior.
-        if lldbtest_config.inferior_env:
-            self.runCmd('settings set target.env-vars {}'.format(lldbtest_config.inferior_env))
-
         if "LLDB_MAX_LAUNCH_COUNT" in os.environ:
             self.maxLaunchCount = int(os.environ["LLDB_MAX_LAUNCH_COUNT"])
 
Index: packages/Python/lldbsuite/test/terminal/TestSTTYBeforeAndAfter.py
===================================================================
--- packages/Python/lldbsuite/test/terminal/TestSTTYBeforeAndAfter.py
+++ packages/Python/lldbsuite/test/terminal/TestSTTYBeforeAndAfter.py
@@ -73,7 +73,7 @@
         child.logfile_read = None
 
         # Invoke the lldb command.
-        child.sendline('%s %s' % (lldbtest_config.lldbExec, self.lldbOption))
+        child.sendline(lldbtest_config.lldbExec)
         child.expect_exact(lldb_prompt)
 
         # Immediately quit.
Index: packages/Python/lldbsuite/test/tools/lldb-vscode/lldbvscode_testcase.py
===================================================================
--- packages/Python/lldbsuite/test/tools/lldb-vscode/lldbvscode_testcase.py
+++ packages/Python/lldbsuite/test/tools/lldb-vscode/lldbvscode_testcase.py
@@ -12,7 +12,7 @@
         self.assertTrue(os.path.exists(self.lldbVSCodeExec),
                         'lldb-vscode must exist')
         self.vscode = vscode.DebugAdaptor(
-            executable=self.lldbVSCodeExec, init_commands=Base.setUpCommands())
+            executable=self.lldbVSCodeExec, init_commands=self.setUpCommands())
 
     def build_and_create_debug_adaptor(self):
         self.build()