diff --git a/clang/include/clang/Tooling/DependencyScanning/DependencyScanningFilesystem.h b/clang/include/clang/Tooling/DependencyScanning/DependencyScanningFilesystem.h
--- a/clang/include/clang/Tooling/DependencyScanning/DependencyScanningFilesystem.h
+++ b/clang/include/clang/Tooling/DependencyScanning/DependencyScanningFilesystem.h
@@ -55,6 +55,11 @@
   /// \returns True if the entry is valid.
   bool isValid() const { return !MaybeStat || MaybeStat->isStatusKnown(); }
 
+  /// \returns True if the current entry points to a directory.
+  bool isDirectory() const {
+    return MaybeStat && MaybeStat->isDirectory();
+  }
+
   /// \returns The error or the file's contents.
   llvm::ErrorOr<StringRef> getContents() const {
     if (!MaybeStat)
diff --git a/clang/lib/Tooling/DependencyScanning/DependencyScanningFilesystem.cpp b/clang/lib/Tooling/DependencyScanning/DependencyScanningFilesystem.cpp
--- a/clang/lib/Tooling/DependencyScanning/DependencyScanningFilesystem.cpp
+++ b/clang/lib/Tooling/DependencyScanning/DependencyScanningFilesystem.cpp
@@ -190,8 +190,11 @@
   StringRef Filename = Path.toStringRef(OwnedFilename);
 
   // Check the local cache first.
-  if (const CachedFileSystemEntry *Entry = getCachedEntry(Filename))
+  if (const CachedFileSystemEntry *Entry = getCachedEntry(Filename)) {
+    if (Entry->isDirectory())
+      return llvm::ErrorOr<std::unique_ptr<llvm::vfs::File>>(std::make_error_code(std::errc::is_a_directory));
     return createFile(Entry);
+  }
 
   // FIXME: Handle PCM/PCH files.
   // FIXME: Handle module map files.
diff --git a/clang/test/ClangScanDeps/Inputs/foodir b/clang/test/ClangScanDeps/Inputs/foodir
new file mode 100644
--- /dev/null
+++ b/clang/test/ClangScanDeps/Inputs/foodir
@@ -0,0 +1 @@
+// A C++ header with same name as that of a directory in the include path.
diff --git a/clang/test/ClangScanDeps/Inputs/headerwithdirname.json b/clang/test/ClangScanDeps/Inputs/headerwithdirname.json
new file mode 100644
--- /dev/null
+++ b/clang/test/ClangScanDeps/Inputs/headerwithdirname.json
@@ -0,0 +1,7 @@
+[
+    {
+      "directory": "DIR",
+      "command": "clang -c -IDIR -IDIR/foodir -IInputs DIR/headerwithdirname.cpp",
+      "file": "DIR/headerwithdirname.cpp"
+    }
+]
diff --git a/clang/test/ClangScanDeps/headerwithdirname.cpp b/clang/test/ClangScanDeps/headerwithdirname.cpp
new file mode 100644
--- /dev/null
+++ b/clang/test/ClangScanDeps/headerwithdirname.cpp
@@ -0,0 +1,17 @@
+// RUN: rm -rf %t.dir
+// RUN: rm -rf %t.dir/foodir
+// RUN: rm -rf %t.cdb
+// RUN: mkdir -p %t.dir
+// RUN: mkdir -p %t.dir/foodir
+// RUN: cp %s %t.dir/headerwithdirname.cpp
+// RUN: mkdir %t.dir/Inputs
+// RUN: cp %S/Inputs/foodir %t.dir/Inputs/foodir
+// RUN: sed -e "s|DIR|%/t.dir|g" %S/Inputs/headerwithdirname.json > %t.cdb
+//
+// RUN: clang-scan-deps -compilation-database %t.cdb -j 1 | FileCheck %s
+
+#include <foodir>
+
+// CHECK: clang-scan-deps dependency
+// CHECK-NEXT: headerwithdirname.cpp
+// CHECK-NEXT: Inputs{{/|\\}}foodir
\ No newline at end of file