Index: lib/Transforms/Vectorize/LoadStoreVectorizer.cpp
===================================================================
--- lib/Transforms/Vectorize/LoadStoreVectorizer.cpp
+++ lib/Transforms/Vectorize/LoadStoreVectorizer.cpp
@@ -339,11 +339,16 @@
                                         const APInt &PtrDelta,
                                         unsigned Depth) const {
   unsigned PtrBitWidth = DL.getPointerTypeSizeInBits(PtrA->getType());
+  unsigned PtrAS = PtrA->getType()->getPointerAddressSpace();
   APInt OffsetA(PtrBitWidth, 0);
   APInt OffsetB(PtrBitWidth, 0);
   PtrA = PtrA->stripAndAccumulateInBoundsConstantOffsets(DL, OffsetA);
   PtrB = PtrB->stripAndAccumulateInBoundsConstantOffsets(DL, OffsetB);
 
+  if (PtrA->getType()->getPointerAddressSpace() != PtrAS ||
+      PtrB->getType()->getPointerAddressSpace() != PtrAS)
+    return false;
+
   APInt OffsetDelta = OffsetB - OffsetA;
 
   // Check if they are based on the same pointer. That makes the offsets
Index: test/Transforms/LoadStoreVectorizer/AMDGPU/vect-ptr-ptr-size-mismatch.ll
===================================================================
--- /dev/null
+++ test/Transforms/LoadStoreVectorizer/AMDGPU/vect-ptr-ptr-size-mismatch.ll
@@ -0,0 +1,18 @@
+; RUN: opt -mtriple=amdgcn-amd-amdhsa -load-store-vectorizer -S < %s | FileCheck %s
+
+target datalayout = "e-p:64:64-p1:64:64-p2:32:32-p3:32:32-p4:64:64-p5:32:32"
+
+; CHECK-LABEL: @test
+; CHECK: store i32* undef, i32** %tmp9, align 8
+; CHECK: store i32* undef, i32** %tmp7, align 8
+define amdgpu_kernel void @test() {
+entry:
+  %a10.ascast.i = addrspacecast i32* addrspace(5)* null to i32**
+  %tmp4 = icmp eq i32 undef, 0
+  %tmp6 = select i1 false, i32** undef, i32** undef
+  %tmp7 = select i1 %tmp4, i32** null, i32** %tmp6
+  %tmp9 = select i1 %tmp4, i32** %a10.ascast.i, i32** null
+  store i32* undef, i32** %tmp9, align 8
+  store i32* undef, i32** %tmp7, align 8
+  unreachable
+}