diff --git a/llvm/lib/Target/WebAssembly/WebAssemblyLowerEmscriptenEHSjLj.cpp b/llvm/lib/Target/WebAssembly/WebAssemblyLowerEmscriptenEHSjLj.cpp
--- a/llvm/lib/Target/WebAssembly/WebAssemblyLowerEmscriptenEHSjLj.cpp
+++ b/llvm/lib/Target/WebAssembly/WebAssemblyLowerEmscriptenEHSjLj.cpp
@@ -520,6 +520,20 @@
       Callee == GetTempRet0Func || Callee == SetTempRet0Func)
     return false;
 
+  // EM_ASM related functions
+  Function *EmAsmConstIntF = M.getFunction("emscripten_asm_const_int");
+  Function *EmAsmConstDoubleF = M.getFunction("emscripten_asm_const_double");
+  Function *EmAsmConstIntSyncMainF =
+      M.getFunction("emscripten_asm_const_int_sync_on_main_thread");
+  Function *EmAsmConstDoubleSyncMainF =
+      M.getFunction("emscripten_asm_const_double_sync_on_main_thread");
+  Function *EmAsmConstAsyncMainF =
+      M.getFunction("emscripten_asm_const_async_on_main_thread");
+  if (Callee == EmAsmConstIntF || Callee == EmAsmConstDoubleF ||
+      Callee == EmAsmConstIntSyncMainF || Callee == EmAsmConstDoubleSyncMainF ||
+      Callee == EmAsmConstAsyncMainF)
+    return false;
+
   // Otherwise we don't know
   return true;
 }
diff --git a/llvm/test/CodeGen/WebAssembly/lower-em-sjlj.ll b/llvm/test/CodeGen/WebAssembly/lower-em-sjlj.ll
--- a/llvm/test/CodeGen/WebAssembly/lower-em-sjlj.ll
+++ b/llvm/test/CodeGen/WebAssembly/lower-em-sjlj.ll
@@ -203,6 +203,24 @@
   ret void
 }
 
+; Test EM_ASM handling
+@em_asm_str = constant [32 x i8] c"{ console.log(\22hello world\22); }\00", align 1
+
+define hidden i32 @em_asm() {
+; CHECK-LABEL: @em_asm
+entry:
+  %env = alloca [1 x %struct.__jmp_buf_tag], align 16
+  %arraydecay = getelementptr inbounds [1 x %struct.__jmp_buf_tag], [1 x %struct.__jmp_buf_tag]* %env, i32 0, i32 0
+  %call = call i32 @setjmp(%struct.__jmp_buf_tag* %arraydecay)
+
+  %.compoundliteral = alloca [1 x i8], align 1
+  %arraydecay1 = getelementptr inbounds [1 x i8], [1 x i8]* %.compoundliteral, i32 0, i32 0
+; CHECK: call i32 (i8*, i8*, ...) @emscripten_asm_const_int
+; CHECK-NOT: @"__invoke_i32_i8*_i8*_..."
+  %call2 = call i32 (i8*, i8*, ...) @emscripten_asm_const_int(i8* getelementptr inbounds ([32 x i8], [32 x i8]* @em_asm_str, i32 0, i32 0), i8* %arraydecay1)
+  ret i32 %call2
+}
+
 declare void @foo()
 ; Function Attrs: returns_twice
 declare i32 @setjmp(%struct.__jmp_buf_tag*) #0
@@ -213,6 +231,7 @@
 declare void @__cxa_end_catch()
 declare i8* @malloc(i32)
 declare void @free(i8*)
+declare i32 @emscripten_asm_const_int(i8*, i8*, ...)
 
 ; JS glue functions and invoke wrappers declaration
 ; CHECK-DAG: declare i32 @getTempRet0()