Index: lldb/lit/lit-lldb-init.in
===================================================================
--- lldb/lit/lit-lldb-init.in
+++ lldb/lit/lit-lldb-init.in
@@ -1,3 +1,4 @@
 # LLDB init file for the LIT tests.
 settings set symbols.enable-external-lookup false
+settings set plugin.process.gdb-remote.packet-timeout 300
 settings set interpreter.echo-comment-commands false
Index: lldb/packages/Python/lldbsuite/test/api/multithreaded/driver.cpp.template
===================================================================
--- lldb/packages/Python/lldbsuite/test/api/multithreaded/driver.cpp.template
+++ lldb/packages/Python/lldbsuite/test/api/multithreaded/driver.cpp.template
@@ -32,6 +32,7 @@
   SBDebugger::Initialize();
   SBDebugger dbg = SBDebugger::Create();
   dbg.HandleCommand("settings set symbols.enable-external-lookup false");
+  dbg.HandleCommand("settings set plugin.process.gdb-remote.packet-timeout 300");
 
   try {
     if (!dbg.IsValid())
Index: lldb/packages/Python/lldbsuite/test/functionalities/gdb_remote_client/TestNoWatchpointSupportInfo.py
===================================================================
--- lldb/packages/Python/lldbsuite/test/functionalities/gdb_remote_client/TestNoWatchpointSupportInfo.py
+++ lldb/packages/Python/lldbsuite/test/functionalities/gdb_remote_client/TestNoWatchpointSupportInfo.py
@@ -21,6 +21,7 @@
             def threadStopInfo(self, threadnum):
                 if threadnum == 0x1ff0d:
                     return "T02thread:1ff0d;thread-pcs:10001bc00;"
+                return ""
 
             def setBreakpoint(self, packet):
                 if packet.startswith("Z2,"):
Index: lldb/packages/Python/lldbsuite/test/lldbtest.py
===================================================================
--- lldb/packages/Python/lldbsuite/test/lldbtest.py
+++ lldb/packages/Python/lldbsuite/test/lldbtest.py
@@ -698,6 +698,17 @@
         """Return absolute path to a file in the test's source directory."""
         return os.path.join(self.getSourceDir(), name)
 
+    @staticmethod
+    def setUpCommands():
+        return [
+            # Disable Spotlight lookup. The testsuite creates
+            # different binaries with the same UUID, because they only
+            # differ in the debug info, which is not being hashed.
+            "settings set symbols.enable-external-lookup false",
+
+            # Testsuite runs in parallel and the host can have also other load.
+            "settings set plugin.process.gdb-remote.packet-timeout 300"]
+
     def setUp(self):
         """Fixture for unittest test case setup.
 
@@ -716,7 +727,7 @@
         else:
             self.lldbVSCodeExec = None
 
-        self.lldbOption = "-o 'settings set symbols.enable-external-lookup false'"
+        self.lldbOption = " ".join("-o '" + s + "'" for s in self.setUpCommands())
 
         # If we spawn an lldb process for test (via pexpect), do not load the
         # init file unless told otherwise.
@@ -1856,10 +1867,8 @@
         self.runCmd('settings set symbols.clang-modules-cache-path "%s"'
                     % mod_cache)
 
-        # Disable Spotlight lookup. The testsuite creates
-        # different binaries with the same UUID, because they only
-        # differ in the debug info, which is not being hashed.
-        self.runCmd('settings set symbols.enable-external-lookup false')
+        for s in self.setUpCommands():
+            self.runCmd(s)
 
         # Disable color.
         self.runCmd("settings set use-color false")
Index: lldb/packages/Python/lldbsuite/test/tools/lldb-vscode/vscode.py
===================================================================
--- lldb/packages/Python/lldbsuite/test/tools/lldb-vscode/vscode.py
+++ lldb/packages/Python/lldbsuite/test/tools/lldb-vscode/vscode.py
@@ -10,6 +10,7 @@
 import subprocess
 import sys
 import threading
+from lldbsuite.test.lldbtest import Base
 
 
 def dump_memory(base_addr, data, num_per_line, outfile):
@@ -447,8 +448,7 @@
             args_dict['waitFor'] = waitFor
         if trace:
             args_dict['trace'] = trace
-        args_dict['initCommands'] = [
-            'settings set symbols.enable-external-lookup false']
+        args_dict['initCommands'] = Base.setUpCommands()
         if initCommands:
             args_dict['initCommands'].extend(initCommands)
         if preRunCommands:
@@ -578,8 +578,7 @@
             args_dict['shellExpandArguments'] = shellExpandArguments
         if trace:
             args_dict['trace'] = trace
-        args_dict['initCommands'] = [
-            'settings set symbols.enable-external-lookup false']
+        args_dict['initCommands'] = Base.setUpCommands()
         if initCommands:
             args_dict['initCommands'].extend(initCommands)
         if preRunCommands:
Index: lldb/tools/lldb-test/lldb-test.cpp
===================================================================
--- lldb/tools/lldb-test/lldb-test.cpp
+++ lldb/tools/lldb-test/lldb-test.cpp
@@ -976,6 +976,12 @@
 
   auto Dbg = lldb_private::Debugger::CreateInstance();
   ModuleList::GetGlobalModuleListProperties().SetEnableExternalLookup(false);
+  // There is no SB API for settings in general like:
+  // GetGlobalPluginProperties()->SetPacketTimeout(std::chrono::seconds(300));
+  CommandReturnObject Result;
+  Dbg->GetCommandInterpreter().HandleCommand(
+      "settings set plugin.process.gdb-remote.packet-timeout 300",
+      /*add_to_history*/ eLazyBoolNo, Result);
 
   if (!opts::Log.empty())
     Dbg->EnableLog("lldb", {"all"}, opts::Log, 0, errs());