Index: lldb/cmake/modules/LLDBConfig.cmake
===================================================================
--- lldb/cmake/modules/LLDBConfig.cmake
+++ lldb/cmake/modules/LLDBConfig.cmake
@@ -199,9 +199,23 @@
     find_package(PythonLibs REQUIRED)
   endif()
 
-  if (NOT PYTHON_VERSION_STRING VERSION_EQUAL PYTHONLIBS_VERSION_STRING AND
-      NOT CMAKE_CROSSCOMPILING)
-    message(FATAL_ERROR "Found incompatible Python interpreter (${PYTHON_VERSION_STRING}) and Python libraries (${PYTHONLIBS_VERSION_STRING})")
+  if (NOT CMAKE_CROSSCOMPILING)
+    # Manually split PYTHON_VERSION_STRING because find_python_libs_windows
+    # doesn't set PYTHON_VERSION_MAJOR or PYTHON_VERSION_MINOR.
+    string(REPLACE "." ";" python_version_list ${PYTHON_VERSION_STRING})
+    string(REPLACE "." ";" pythonlibs_version_list ${PYTHONLIBS_VERSION_STRING})
+    list(GET python_version_list 0 python_major)
+    list(GET python_version_list 1 python_minor)
+    list(GET pythonlibs_version_list 0 pythonlibs_major)
+    list(GET pythonlibs_version_list 1 pythonlibs_minor)
+
+    # Ignore the patch version. Some versions of macOS report a different patch
+    # version for the system provided interpreter and libraries.
+    if (NOT python_major VERSION_EQUAL pythonlibs_major OR
+        NOT python_minor VERSION_EQUAL pythonlibs_minor)
+      message(FATAL_ERROR "Found incompatible Python interpreter (${python_major}.${python_minor})"
+                          " and Python libraries (${pythonlibs_major}.${pythonlibs_minor})")
+    endif()
   endif()
 
   if (PYTHON_INCLUDE_DIR)