diff --git a/llvm/lib/Target/WebAssembly/WebAssemblyLowerEmscriptenEHSjLj.cpp b/llvm/lib/Target/WebAssembly/WebAssemblyLowerEmscriptenEHSjLj.cpp
--- a/llvm/lib/Target/WebAssembly/WebAssemblyLowerEmscriptenEHSjLj.cpp
+++ b/llvm/lib/Target/WebAssembly/WebAssemblyLowerEmscriptenEHSjLj.cpp
@@ -485,6 +485,13 @@
     if (CalleeF->isIntrinsic())
       return false;
 
+  // Attempting to transform inline assembly will result in something like:
+  //     call void @__invoke_void(void ()* asm ...)
+  // which is invalid because inline assembly blocks do not have addresses
+  // and can't be passed by pointer. The result is a crash with illegal IR.
+  if (isa<InlineAsm>(Callee))
+    return false;
+
   // The reason we include malloc/free here is to exclude the malloc/free
   // calls generated in setjmp prep / cleanup routines.
   Function *SetjmpF = M.getFunction("setjmp");
diff --git a/llvm/test/CodeGen/WebAssembly/lower-em-sjlj.ll b/llvm/test/CodeGen/WebAssembly/lower-em-sjlj.ll
--- a/llvm/test/CodeGen/WebAssembly/lower-em-sjlj.ll
+++ b/llvm/test/CodeGen/WebAssembly/lower-em-sjlj.ll
@@ -188,6 +188,27 @@
 ; CHECK-NEXT: call void @emscripten_longjmp_jmpbuf(%struct.__jmp_buf_tag* %[[ARRAYDECAY]], i32 5) #1
 }
 
+; Test inline asm handling
+define hidden void @inline_asm() #0 {
+; CHECK-LABEL: @inline_asm
+entry:
+  %env = alloca [1 x %struct.__jmp_buf_tag], align 16
+  %arraydecay = getelementptr inbounds [1 x %struct.__jmp_buf_tag], [1 x %struct.__jmp_buf_tag]* %env, i32 0, i32 0
+  %call = call i32 @setjmp(%struct.__jmp_buf_tag* %arraydecay) #4
+  %cmp = icmp eq i32 %call, 0
+  br i1 %cmp, label %if.then, label %if.else
+
+if.then:                                          ; preds = %entry
+; CHECK: call void asm sideeffect "", ""()
+  call void asm sideeffect "", ""()
+  %arraydecay1 = getelementptr inbounds [1 x %struct.__jmp_buf_tag], [1 x %struct.__jmp_buf_tag]* %env, i32 0, i32 0
+  call void @longjmp(%struct.__jmp_buf_tag* %arraydecay1, i32 1) #5
+  unreachable
+
+if.else:                                          ; preds = %entry
+  ret void
+}
+
 declare void @foo()
 ; Function Attrs: returns_twice
 declare i32 @setjmp(%struct.__jmp_buf_tag*) #0