diff --git a/llvm/lib/Transforms/InstCombine/InstCombineCalls.cpp b/llvm/lib/Transforms/InstCombine/InstCombineCalls.cpp
--- a/llvm/lib/Transforms/InstCombine/InstCombineCalls.cpp
+++ b/llvm/lib/Transforms/InstCombine/InstCombineCalls.cpp
@@ -1194,6 +1194,12 @@
     return CallInst::Create(F, {X, II.getArgOperand(1)});
   }
 
+  // cttz(-x) -> cttz(x)
+  if (IsTZ && match(Op0, m_Neg(m_Value(X)))) {
+    II.setOperand(0, X);
+    return ⅈ
+  }
+
   KnownBits Known = IC.computeKnownBits(Op0, 0, &II);
 
   // Create a mask for bits above (ctlz) or below (cttz) the first known one.
diff --git a/llvm/test/Transforms/InstCombine/cttz-negative.ll b/llvm/test/Transforms/InstCombine/cttz-negative.ll
--- a/llvm/test/Transforms/InstCombine/cttz-negative.ll
+++ b/llvm/test/Transforms/InstCombine/cttz-negative.ll
@@ -3,44 +3,53 @@
 
 define i32 @cttz_neg_value(i32 %x) {
 ; CHECK-LABEL: @cttz_neg_value(
-; CHECK-NEXT:    [[A:%.*]] = sub nsw i32 0, [[X:%.*]]
-; CHECK-NEXT:    [[B:%.*]] = call i32 @llvm.cttz.i32(i32 [[A]], i1 false), !range !0
+; CHECK-NEXT:    [[B:%.*]] = call i32 @llvm.cttz.i32(i32 [[X:%.*]], i1 false), !range !0
+; CHECK-NEXT:    ret i32 [[B]]
+;
+  %a = sub i32 0, %x
+  %b = tail call i32 @llvm.cttz.i32(i32 %a)
+  ret i32 %b
+}
+
+define i32 @cttz_neg_value_multiuse(i32 %x) {
+; CHECK-LABEL: @cttz_neg_value_multiuse(
+; CHECK-NEXT:    [[A:%.*]] = sub i32 0, [[X:%.*]]
+; CHECK-NEXT:    call void @use(i32 [[A]])
+; CHECK-NEXT:    [[B:%.*]] = call i32 @llvm.cttz.i32(i32 [[X]], i1 false), !range !0
 ; CHECK-NEXT:    ret i32 [[B]]
 ;
-  %a = sub nsw i32 0, %x
+  %a = sub i32 0, %x
+  call void @use(i32 %a)
   %b = tail call i32 @llvm.cttz.i32(i32 %a)
   ret i32 %b
 }
 
 define i64 @cttz_neg_value_64(i64 %x) {
 ; CHECK-LABEL: @cttz_neg_value_64(
-; CHECK-NEXT:    [[A:%.*]] = sub nsw i64 0, [[X:%.*]]
-; CHECK-NEXT:    [[B:%.*]] = tail call i64 @llvm.cttz.i64(i64 [[A]], i1 true), !range !1
+; CHECK-NEXT:    [[B:%.*]] = tail call i64 @llvm.cttz.i64(i64 [[X:%.*]], i1 true), !range !1
 ; CHECK-NEXT:    ret i64 [[B]]
 ;
-  %a = sub nsw i64 0, %x
+  %a = sub i64 0, %x
   %b = tail call i64 @llvm.cttz.i64(i64 %a, i1 true)
   ret i64 %b
 }
 
 define i64 @cttz_neg_value2_64(i64 %x) {
 ; CHECK-LABEL: @cttz_neg_value2_64(
-; CHECK-NEXT:    [[A:%.*]] = sub nsw i64 0, [[X:%.*]]
-; CHECK-NEXT:    [[B:%.*]] = tail call i64 @llvm.cttz.i64(i64 [[A]], i1 false), !range !1
+; CHECK-NEXT:    [[B:%.*]] = tail call i64 @llvm.cttz.i64(i64 [[X:%.*]], i1 false), !range !1
 ; CHECK-NEXT:    ret i64 [[B]]
 ;
-  %a = sub nsw i64 0, %x
+  %a = sub i64 0, %x
   %b = tail call i64 @llvm.cttz.i64(i64 %a, i1 false)
   ret i64 %b
 }
 
 define <2 x i64> @cttz_neg_value_vec(<2 x i64> %x) {
 ; CHECK-LABEL: @cttz_neg_value_vec(
-; CHECK-NEXT:    [[A:%.*]] = sub nsw <2 x i64> zeroinitializer, [[X:%.*]]
-; CHECK-NEXT:    [[B:%.*]] = call <2 x i64> @llvm.cttz.v2i64(<2 x i64> [[A]], i1 false)
+; CHECK-NEXT:    [[B:%.*]] = call <2 x i64> @llvm.cttz.v2i64(<2 x i64> [[X:%.*]], i1 false)
 ; CHECK-NEXT:    ret <2 x i64> [[B]]
 ;
-  %a = sub nsw  <2 x i64> zeroinitializer, %x
+  %a = sub  <2 x i64> zeroinitializer, %x
   %b = tail call <2 x i64> @llvm.cttz.v2i64(<2 x i64> %a)
   ret <2 x i64> %b
 }
@@ -49,26 +58,27 @@
 
 define i32 @cttz_nonneg_value(i32 %x) {
 ; CHECK-LABEL: @cttz_nonneg_value(
-; CHECK-NEXT:    [[A:%.*]] = sub nsw i32 1, [[X:%.*]]
+; CHECK-NEXT:    [[A:%.*]] = sub i32 1, [[X:%.*]]
 ; CHECK-NEXT:    [[B:%.*]] = call i32 @llvm.cttz.i32(i32 [[A]], i1 false), !range !0
 ; CHECK-NEXT:    ret i32 [[B]]
 ;
-  %a = sub nsw i32 1, %x
+  %a = sub i32 1, %x
   %b = tail call i32 @llvm.cttz.i32(i32 %a)
   ret i32 %b
 }
 
 define <2 x i64> @cttz_nonneg_value_vec(<2 x i64> %x) {
 ; CHECK-LABEL: @cttz_nonneg_value_vec(
-; CHECK-NEXT:    [[A:%.*]] = sub nsw <2 x i64> <i64 1, i64 0>, [[X:%.*]]
+; CHECK-NEXT:    [[A:%.*]] = sub <2 x i64> <i64 1, i64 0>, [[X:%.*]]
 ; CHECK-NEXT:    [[B:%.*]] = call <2 x i64> @llvm.cttz.v2i64(<2 x i64> [[A]], i1 false)
 ; CHECK-NEXT:    ret <2 x i64> [[B]]
 ;
-  %a = sub nsw  <2 x i64> <i64 1, i64 0>, %x
+  %a = sub  <2 x i64> <i64 1, i64 0>, %x
   %b = tail call <2 x i64> @llvm.cttz.v2i64(<2 x i64> %a)
   ret <2 x i64> %b
 }
 
+declare void @use(i32 %a)
 declare i32 @llvm.cttz.i32(i32)
 declare i64 @llvm.cttz.i64(i64, i1)
 declare <2 x i64> @llvm.cttz.v2i64(<2 x i64>)