Index: llvm/trunk/lib/Transforms/Utils/PredicateInfo.cpp
===================================================================
--- llvm/trunk/lib/Transforms/Utils/PredicateInfo.cpp
+++ llvm/trunk/lib/Transforms/Utils/PredicateInfo.cpp
@@ -473,7 +473,8 @@
   }
   for (auto &Assume : AC.assumptions()) {
     if (auto *II = dyn_cast_or_null<IntrinsicInst>(Assume))
-      processAssume(II, II->getParent(), OpsToRename);
+      if (DT.isReachableFromEntry(II->getParent()))
+        processAssume(II, II->getParent(), OpsToRename);
   }
   // Now rename all our operations.
   renameUses(OpsToRename);
Index: llvm/trunk/test/Transforms/Util/PredicateInfo/unreachable.ll
===================================================================
--- llvm/trunk/test/Transforms/Util/PredicateInfo/unreachable.ll
+++ llvm/trunk/test/Transforms/Util/PredicateInfo/unreachable.ll
@@ -0,0 +1,25 @@
+; RUN: opt -print-predicateinfo < %s 2>&1 | FileCheck %s
+
+declare void @foo()
+declare void @llvm.assume(i1)
+
+define void @bar(i32* %p) {
+entry:
+; CHECK-LABEL: @bar
+  br label %end
+
+unreachable1:
+  %v1 = load i32, i32* %p, align 4
+  %c1 = icmp eq i32 %v1, 0
+  call void @llvm.assume(i1 %c1)
+  br label %unreachable2
+
+unreachable2:
+  %v2 = load i32, i32* %p, align 4
+  %c2 = icmp eq i32 %v2, 0
+  call void @llvm.assume(i1 %c2)
+  br label %end
+
+end:
+  ret void
+}