Index: lib/Target/AMDGPU/AMDGPUISelLowering.cpp
===================================================================
--- lib/Target/AMDGPU/AMDGPUISelLowering.cpp
+++ lib/Target/AMDGPU/AMDGPUISelLowering.cpp
@@ -3712,6 +3712,8 @@
       RHS = RHS.getOperand(0);
 
     SDValue Res = DAG.getNode(ISD::FADD, SL, VT, LHS, RHS, N0->getFlags());
+    if (Res.getOpcode() != ISD::FADD)
+      return SDValue(); // Op got folded away.
     if (!N0.hasOneUse())
       DAG.ReplaceAllUsesWith(N0, DAG.getNode(ISD::FNEG, SL, VT, Res));
     return Res;
@@ -3731,6 +3733,8 @@
       RHS = DAG.getNode(ISD::FNEG, SL, VT, RHS);
 
     SDValue Res = DAG.getNode(Opc, SL, VT, LHS, RHS, N0->getFlags());
+    if (Res.getOpcode() != Opc)
+      return SDValue(); // Op got folded away.
     if (!N0.hasOneUse())
       DAG.ReplaceAllUsesWith(N0, DAG.getNode(ISD::FNEG, SL, VT, Res));
     return Res;
@@ -3758,6 +3762,8 @@
       RHS = RHS.getOperand(0);
 
     SDValue Res = DAG.getNode(Opc, SL, VT, LHS, MHS, RHS);
+    if (Res.getOpcode() != Opc)
+      return SDValue(); // Op got folded away.
     if (!N0.hasOneUse())
       DAG.ReplaceAllUsesWith(N0, DAG.getNode(ISD::FNEG, SL, VT, Res));
     return Res;
@@ -3786,6 +3792,8 @@
     unsigned Opposite = inverseMinMax(Opc);
 
     SDValue Res = DAG.getNode(Opposite, SL, VT, NegLHS, NegRHS, N0->getFlags());
+    if (Res.getOpcode() != Opposite)
+      return SDValue(); // Op got folded away.
     if (!N0.hasOneUse())
       DAG.ReplaceAllUsesWith(N0, DAG.getNode(ISD::FNEG, SL, VT, Res));
     return Res;
@@ -3796,6 +3804,8 @@
       Ops[I] = DAG.getNode(ISD::FNEG, SL, VT, N0->getOperand(I), N0->getFlags());
 
     SDValue Res = DAG.getNode(AMDGPUISD::FMED3, SL, VT, Ops, N0->getFlags());
+    if (Res.getOpcode() != AMDGPUISD::FMED3)
+      return SDValue(); // Op got folded away.
     if (!N0.hasOneUse())
       DAG.ReplaceAllUsesWith(N0, DAG.getNode(ISD::FNEG, SL, VT, Res));
     return Res;
Index: test/CodeGen/AMDGPU/fneg-combines.ll
===================================================================
--- test/CodeGen/AMDGPU/fneg-combines.ll
+++ test/CodeGen/AMDGPU/fneg-combines.ll
@@ -214,6 +214,28 @@
   ret void
 }
 
+; This one asserted with -enable-no-signed-zeros-fp-math
+; GCN-LABEL: {{^}}fneg_fadd_0:
+; GCN-SAFE-DAG: v_mad_f32 [[A:v[0-9]+]],
+; GCN-SAFE-DAG: v_xor_b32_e32 [[B:v[0-9]+]], 0x80000000
+; GCN-SAFE-DAG: v_cmp_ngt_f32_e32 {{.*}}, [[A]]
+; GCN-NSZ-DAG: v_mac_f32_e32 [[C:v[0-9]+]],
+; GCN-NSZ-DAG: v_cmp_nlt_f32_e64 {{.*}}, -[[C]]
+
+define amdgpu_ps float @fneg_fadd_0(float inreg %tmp2, float inreg %tmp6, <4 x i32> %arg) local_unnamed_addr #0 {
+.entry:
+  %tmp7 = fdiv float 1.000000e+00, %tmp6
+  %tmp8 = fmul float 0.000000e+00, %tmp7
+  %tmp9 = fmul reassoc nnan arcp contract float 0.000000e+00, %tmp8
+  %.i188 = fadd float %tmp9, 0.000000e+00
+  %tmp10 = fcmp uge float %.i188, %tmp2
+  %tmp11 = fsub float -0.000000e+00, %.i188
+  %.i092 = select i1 %tmp10, float %tmp2, float %tmp11
+  %tmp12 = fcmp ule float %.i092, 0.000000e+00
+  %.i198 = select i1 %tmp12, float 0.000000e+00, float 0x7FF8000000000000
+  ret float %.i198
+}
+
 ; --------------------------------------------------------------------------------
 ; fmul tests
 ; --------------------------------------------------------------------------------