diff --git a/clang/include/clang/Basic/LangOptions.def b/clang/include/clang/Basic/LangOptions.def
--- a/clang/include/clang/Basic/LangOptions.def
+++ b/clang/include/clang/Basic/LangOptions.def
@@ -217,6 +217,8 @@
 LANGOPT(CUDADeviceApproxTranscendentals, 1, 0, "using approximate transcendental functions")
 LANGOPT(GPURelocatableDeviceCode, 1, 0, "generate relocatable device code")
 
+LANGOPT(SYCLIsDevice      , 1, 0, "Generate code for SYCL device")
+
 LANGOPT(SizedDeallocation , 1, 0, "sized deallocation")
 LANGOPT(AlignedAllocation , 1, 0, "aligned allocation")
 LANGOPT(AlignedAllocationUnavailable, 1, 0, "aligned allocation functions are unavailable")
diff --git a/clang/include/clang/Driver/CC1Options.td b/clang/include/clang/Driver/CC1Options.td
--- a/clang/include/clang/Driver/CC1Options.td
+++ b/clang/include/clang/Driver/CC1Options.td
@@ -836,8 +836,14 @@
 def fopenmp_host_ir_file_path : Separate<["-"], "fopenmp-host-ir-file-path">,
   HelpText<"Path to the IR file produced by the frontend for the host.">;
 
-} // let Flags = [CC1Option]
+//===----------------------------------------------------------------------===//
+// SYCL Options
+//===----------------------------------------------------------------------===//
 
+def fsycl_is_device : Flag<["-"], "fsycl-is-device">,
+  HelpText<"Generate code for SYCL device.">;
+
+} // let Flags = [CC1Option]
 
 //===----------------------------------------------------------------------===//
 // cc1as-only Options
diff --git a/clang/lib/Frontend/CompilerInvocation.cpp b/clang/lib/Frontend/CompilerInvocation.cpp
--- a/clang/lib/Frontend/CompilerInvocation.cpp
+++ b/clang/lib/Frontend/CompilerInvocation.cpp
@@ -2879,6 +2879,8 @@
           << Opts.OMPHostIRFile;
   }
 
+  Opts.SYCLIsDevice = Args.hasArg(options::OPT_fsycl_is_device);
+
   // Set CUDA mode for OpenMP target NVPTX if specified in options
   Opts.OpenMPCUDAMode = Opts.OpenMPIsDevice && T.isNVPTX() &&
                         Args.hasArg(options::OPT_fopenmp_cuda_mode);
diff --git a/clang/lib/Frontend/InitPreprocessor.cpp b/clang/lib/Frontend/InitPreprocessor.cpp
--- a/clang/lib/Frontend/InitPreprocessor.cpp
+++ b/clang/lib/Frontend/InitPreprocessor.cpp
@@ -1057,6 +1057,12 @@
     Builder.defineMacro("__CLANG_CUDA_APPROX_TRANSCENDENTALS__");
   }
 
+  // Define indicating that the source file is being compiled with a SYCL
+  // device compiler which doesn't produce host binary.
+  if (LangOpts.SYCLIsDevice) {
+    Builder.defineMacro("__SYCL_DEVICE_ONLY__", "1");
+  }
+
   // OpenCL definitions.
   if (LangOpts.OpenCL) {
 #define OPENCLEXT(Ext)                                                         \
diff --git a/clang/test/Preprocessor/sycl-macro.cpp b/clang/test/Preprocessor/sycl-macro.cpp
new file mode 100644
--- /dev/null
+++ b/clang/test/Preprocessor/sycl-macro.cpp
@@ -0,0 +1,5 @@
+// RUN: %clang_cc1 %s -E -dM | FileCheck %s
+// RUN: %clang_cc1 %s -fsycl-is-device -E -dM | FileCheck --check-prefix=CHECK-SYCL %s
+
+// CHECK-NOT:#define __SYCL_DEVICE_ONLY__ 1
+// CHECK-SYCL:#define __SYCL_DEVICE_ONLY__ 1