Index: llvm/include/llvm/Analysis/DependenceAnalysis.h
===================================================================
--- llvm/include/llvm/Analysis/DependenceAnalysis.h
+++ llvm/include/llvm/Analysis/DependenceAnalysis.h
@@ -275,6 +275,10 @@
                    LoopInfo *LI)
         : AA(AA), SE(SE), LI(LI), F(F) {}
 
+    /// Handle transitive invalidation when the cached analysis results go away.
+    bool invalidate(Function &F, const PreservedAnalyses &PA,
+                    FunctionAnalysisManager::Invalidator &Inv);
+
     /// depends - Tests for a dependence between the Src and Dst instructions.
     /// Returns NULL if no dependence; otherwise, returns a Dependence (or a
     /// FullDependence) with as much information as can be gleaned.
Index: llvm/lib/Analysis/DependenceAnalysis.cpp
===================================================================
--- llvm/lib/Analysis/DependenceAnalysis.cpp
+++ llvm/lib/Analysis/DependenceAnalysis.cpp
@@ -3369,6 +3369,19 @@
 }
 #endif
 
+bool DependenceInfo::invalidate(Function &F, const PreservedAnalyses &PA,
+                                FunctionAnalysisManager::Invalidator &Inv) {
+  // Check if the analysis itself has been invalidated.
+  auto PAC = PA.getChecker<DependenceAnalysis>();
+  if (!PAC.preserved() && !PAC.preservedSet<AllAnalysesOn<Function>>())
+    return true;
+
+  // Check transitive dependencies.
+  return Inv.invalidate<AAManager>(F, PA) ||
+         Inv.invalidate<ScalarEvolutionAnalysis>(F, PA) ||
+         Inv.invalidate<LoopAnalysis>(F, PA);
+}
+
 // depends -
 // Returns NULL if there is no dependence.
 // Otherwise, return a Dependence with as many details as possible.
Index: llvm/test/Analysis/DependenceAnalysis/new-pm-invalidation.ll
===================================================================
--- /dev/null
+++ llvm/test/Analysis/DependenceAnalysis/new-pm-invalidation.ll
@@ -0,0 +1,16 @@
+; RUN: opt < %s -passes='require<da>,invalidate<scalar-evolution>,print<da>'   \
+; RUN:   -disable-output -debug-pass-manager 2>&1 | FileCheck %s
+
+; CHECK: Running analysis: DependenceAnalysis on test_no_noalias
+; CHECK: Running analysis: ScalarEvolutionAnalysis on test_no_noalias
+; CHECK: Invalidating analysis: ScalarEvolutionAnalysis on test_no_noalias
+; CHECK: Invalidating analysis: DependenceAnalysis on test_no_noalias
+; CHECK: Running analysis: DependenceAnalysis on test_no_noalias
+; CHECK: da analyze - none!
+; CHECK: da analyze - confused!
+; CHECK: da analyze - none!
+define void @test_no_noalias(i32* %A, i32* %B) {
+  store i32 1, i32* %A
+  store i32 2, i32* %B
+  ret void
+}