diff --git a/llvm/include/llvm/Analysis/VectorUtils.h b/llvm/include/llvm/Analysis/VectorUtils.h
--- a/llvm/include/llvm/Analysis/VectorUtils.h
+++ b/llvm/include/llvm/Analysis/VectorUtils.h
@@ -17,6 +17,7 @@
 #include "llvm/Analysis/LoopAccessAnalysis.h"
 #include "llvm/Analysis/TargetLibraryInfo.h"
 #include "llvm/IR/IRBuilder.h"
+#include "llvm/Support/CheckedArithmetic.h"
 
 namespace llvm {
 
@@ -277,7 +278,11 @@
   bool insertMember(InstTy *Instr, int32_t Index, uint32_t NewAlign) {
     assert(NewAlign && "The new member's alignment should be non-zero");
 
-    int32_t Key = Index + SmallestKey;
+    // Make sure the key fits in an int32_t.
+    Optional<int32_t> MaybeKey = checkedAdd(Index, SmallestKey);
+    if (!MaybeKey)
+      return false;
+    int32_t Key = *MaybeKey;
 
     // Skip if there is already a member with the same index.
     if (Members.find(Key) != Members.end())
@@ -285,13 +290,19 @@
 
     if (Key > LargestKey) {
       // The largest index is always less than the interleave factor.
-      if (Index >= static_cast<int>(Factor))
+      if (Index >= static_cast<int32_t>(Factor))
         return false;
 
       LargestKey = Key;
     } else if (Key < SmallestKey) {
+
+      // Make sure the largest index fits in an int32_t.
+      Optional<int32_t> MaybeLargestIndex = checkedSub(LargestKey, Key);
+      if (!MaybeLargestIndex)
+        return false;
+
       // The largest index is always less than the interleave factor.
-      if (LargestKey - Key >= static_cast<int>(Factor))
+      if (*MaybeLargestIndex >= static_cast<int64_t>(Factor))
         return false;
 
       SmallestKey = Key;
diff --git a/llvm/include/llvm/Support/CheckedArithmetic.h b/llvm/include/llvm/Support/CheckedArithmetic.h
--- a/llvm/include/llvm/Support/CheckedArithmetic.h
+++ b/llvm/include/llvm/Support/CheckedArithmetic.h
@@ -49,6 +49,15 @@
   return checkedOp(LHS, RHS, &llvm::APInt::sadd_ov);
 }
 
+/// Subtract two signed integers \p LHS and \p RHS.
+/// \return Optional of sum if no signed overflow occurred,
+/// \c None otherwise.
+template <typename T>
+typename std::enable_if<std::is_signed<T>::value, llvm::Optional<T>>::type
+checkedSub(T LHS, T RHS) {
+  return checkedOp(LHS, RHS, &llvm::APInt::ssub_ov);
+}
+
 /// Multiply two signed integers \p LHS and \p RHS.
 /// \return Optional of product if no signed overflow occurred,
 /// \c None otherwise.
diff --git a/llvm/test/Transforms/LoopVectorize/X86/interleaved-accesses-large-gap.ll b/llvm/test/Transforms/LoopVectorize/X86/interleaved-accesses-large-gap.ll
new file mode 100644
--- /dev/null
+++ b/llvm/test/Transforms/LoopVectorize/X86/interleaved-accesses-large-gap.ll
@@ -0,0 +1,40 @@
+; RUN: opt < %s  -loop-vectorize -mtriple x86_64 -S | FileCheck %s
+
+%struct.ST4 = type { i32, i32, i32, i32 }
+
+; The gaps between the memory access in this function are too large for
+; interleaving.
+
+; Test from https://bugs.chromium.org/p/oss-fuzz/issues/detail?id=7560
+define void @test1(%struct.ST4* noalias %B) {
+; CHECK-LABEL: @test1
+; CHECK-NEXT:  entry:
+; CHECK-NEXT:    br label %for.body
+
+; CHECK-LABEL: for.body:
+; CHECK: store i32
+; CHECK: store i32
+; CHECK: store i32
+; CHECK: store i32
+; CHECK-NOT: store
+;
+entry:
+  br label %for.body
+
+for.body:                                         ; preds = %for.body, %entry
+  %indvars.iv = phi i64 [ 0, %entry ], [ %indvars.iv.next, %for.body ]
+  %p1 = getelementptr inbounds %struct.ST4, %struct.ST4* %B, i64 %indvars.iv, i32 0
+  store i32 65536, i32* %p1, align 4
+  %p2 = getelementptr i32, i32* %p1, i32 -2147483648
+  store i32 65536, i32* %p2, align 4
+  %p3 = getelementptr inbounds %struct.ST4, %struct.ST4* %B, i64 %indvars.iv, i32 2
+  store i32 10, i32* %p3, align 4
+  %p4 = getelementptr inbounds %struct.ST4, %struct.ST4* %B, i64 %indvars.iv, i32 3
+  store i32 12, i32* %p4, align 4
+  %indvars.iv.next = add nuw nsw i64 %indvars.iv, 1
+  %exitcond = icmp eq i64 %indvars.iv.next, 1024
+  br i1 %exitcond, label %for.cond.cleanup, label %for.body
+
+for.cond.cleanup:                                 ; preds = %for.body
+  ret void
+}