Index: clangd/index/SymbolCollector.cpp
===================================================================
--- clangd/index/SymbolCollector.cpp
+++ clangd/index/SymbolCollector.cpp
@@ -211,7 +211,10 @@
                                           const SymbolCollector::Options &Opts,
                                           const clang::LangOptions &LangOpts,
                                           std::string &FileURIStorage) {
-  auto U = toURI(SM, SM.getFilename(TokLoc), Opts);
+  llvm::StringRef FileName = SM.getFilename(TokLoc);
+  if (FileName.empty())
+    return None;
+  auto U = toURI(SM, FileName, Opts);
   if (!U)
     return None;
   FileURIStorage = std::move(*U);
Index: unittests/clangd/SymbolCollectorTests.cpp
===================================================================
--- unittests/clangd/SymbolCollectorTests.cpp
+++ unittests/clangd/SymbolCollectorTests.cpp
@@ -1028,6 +1028,15 @@
                   AllOf(QName("Public"), Not(ImplementationDetail()))));
 }
 
+TEST_F(SymbolCollectorTest, RenameSymbolWithMacro) {
+  const std::string Header = R"(
+  void foo() {}
+  )";
+  runSymbolCollector(Header, /*Main=*/"", {"-Dfoo=bar"});
+  EXPECT_THAT(Symbols, UnorderedElementsAre(QName("bar")));
+}
+
+
 } // namespace
 } // namespace clangd
 } // namespace clang