Index: llvm/trunk/lib/Analysis/MemorySSAUpdater.cpp
===================================================================
--- llvm/trunk/lib/Analysis/MemorySSAUpdater.cpp
+++ llvm/trunk/lib/Analysis/MemorySSAUpdater.cpp
@@ -266,16 +266,15 @@
     for (auto UI = DefBefore->use_begin(), UE = DefBefore->use_end();
          UI != UE;) {
       Use &U = *UI++;
-      // Leave the uses alone
-      if (isa<MemoryUse>(U.getUser()))
+      // Leave the MemoryUses alone.
+      // Also make sure we skip ourselves to avoid self references.
+      if (isa<MemoryUse>(U.getUser()) || U.getUser() == MD)
         continue;
       U.set(MD);
     }
   }
 
   // and that def is now our defining access.
-  // We change them in this order otherwise we will appear in the use list
-  // above and reset ourselves.
   MD->setDefiningAccess(DefBefore);
 
   SmallVector<WeakVH, 8> FixupList(InsertedPHIs.begin(), InsertedPHIs.end());
Index: llvm/trunk/test/Transforms/GVNHoist/pr38807.ll
===================================================================
--- llvm/trunk/test/Transforms/GVNHoist/pr38807.ll
+++ llvm/trunk/test/Transforms/GVNHoist/pr38807.ll
@@ -0,0 +1,50 @@
+; RUN: opt < %s -early-cse-memssa -gvn-hoist -S | FileCheck %s
+
+; Make sure opt doesn't crash. On top of that, the instructions
+; of the side blocks should be hoisted to the entry block.
+
+%s = type { i32, i64 }
+%S = type { %s, i32 }
+
+;CHECK-LABEL: @foo
+
+define void @foo(i32* %arg) {
+bb0:
+  %0 = bitcast i32* %arg to %S*
+  %call.idx.i = getelementptr %S, %S* %0, i64 0, i32 0, i32 0
+  %call.idx.val.i = load i32, i32* %call.idx.i
+  br label %bb1
+
+;CHECK: bb1:
+;CHECK:   %call264 = call zeroext i1 @bar
+;CHECK:   store i32 %call.idx.val.i, i32* %call.idx.i
+;CHECK:   %1 = getelementptr inbounds %S, %S* %0, i64 0, i32 0, i32 1
+;CHECK:   store i64 undef, i64* %1
+;CHECK:   br i1 %call264, label %bb2, label %bb3
+
+bb1:
+  %call264 = call zeroext i1 @bar()
+  br i1 %call264, label %bb2, label %bb3
+
+;CHECK:     bb2:
+;CHECK-NOT:   store i32 %call.idx.val.i, i32* %call.idx.i
+;CHECK-NOT:   store i64 undef, i64* %{.*}
+
+bb2:
+  store i32 %call.idx.val.i, i32* %call.idx.i
+  %1 = getelementptr inbounds %S, %S* %0, i64 0, i32 0, i32 1
+  store i64 undef, i64* %1
+  ret void
+
+;CHECK:     bb3:
+;CHECK-NOT:   store i32 %call.idx.val.i, i32* %call.idx.i
+;CHECK-NOT:   store i64 undef, i64* %{.*}
+
+bb3:
+  store i32 %call.idx.val.i, i32* %call.idx.i
+  %2 = getelementptr inbounds %S, %S* %0, i64 0, i32 0, i32 1
+  store i64 undef, i64* %2
+  ret void
+}
+
+declare zeroext i1 @bar()