Index: clang-tidy/readability/SimplifyBooleanExprCheck.cpp
===================================================================
--- clang-tidy/readability/SimplifyBooleanExprCheck.cpp
+++ clang-tidy/readability/SimplifyBooleanExprCheck.cpp
@@ -75,6 +75,8 @@
 
 bool needsParensAfterUnaryNegation(const Expr *E) {
   E = E->IgnoreImpCasts();
+  if (auto *EC = dyn_cast<ExprWithCleanups>(E))
+    E = EC->getSubExpr();
   if (isa<BinaryOperator>(E) || isa<ConditionalOperator>(E))
     return true;
 
Index: test/clang-tidy/readability-simplify-bool-expr.cpp
===================================================================
--- test/clang-tidy/readability-simplify-bool-expr.cpp
+++ test/clang-tidy/readability-simplify-bool-expr.cpp
@@ -938,3 +938,15 @@
 }
 // CHECK-MESSAGES: :[[@LINE-5]]:12: warning: {{.*}} in conditional return
 // CHECK-FIXES: return p->m != 0;{{$}}
+
+bool operator!=(const A&, const A&) { return false; }
+extern bool GetValue(A s);
+bool expr_with_cleanups(A &s) {
+  A S;
+  if (GetValue(s) && S != (A)s)
+    return false;
+
+  return true;
+}
+// CHECK-MESSAGES: :[[@LINE-4]]:12: warning: {{.*}} in conditional return
+// CHECK-FIXES: !(GetValue(s) && S != (A)s);{{$}}