Index: lib/Transforms/Scalar/CallSiteSplitting.cpp
===================================================================
--- lib/Transforms/Scalar/CallSiteSplitting.cpp
+++ lib/Transforms/Scalar/CallSiteSplitting.cpp
@@ -397,6 +397,14 @@
 static bool tryToSplitCallSite(CallSite CS, TargetTransformInfo &TTI) {
   if (!CS.arg_size() || !canSplitCallSite(CS, TTI))
     return false;
+
+  // musttail calls can't be naively splitted. The split blocks must include
+  // not only the call instruction itself, but also (optional) bitcast and
+  // return instructions that follow it.
+  //
+  // TODO: Implement proper splitting
+  if (CS.isMustTailCall())
+    return false;
   return tryToSplitOnPredicatedArgument(CS) ||
          tryToSplitOnPHIPredicatedArgument(CS);
 }
Index: test/Transforms/CallSiteSplitting/musttail.ll
===================================================================
--- /dev/null
+++ test/Transforms/CallSiteSplitting/musttail.ll
@@ -0,0 +1,19 @@
+; RUN: opt < %s -callsite-splitting -S
+
+define i8* @caller(i8* %a, i8* %b) {
+  %c = icmp eq i8* %a, null
+  br i1 %c, label %Tail, label %TBB
+TBB:
+  %c2 = icmp eq i8* %b, null
+  br i1 %c2, label %Tail, label %End
+Tail:
+  %ca = musttail call i8* @callee(i8* %a, i8* %b)
+  %cb = bitcast i8* %ca to i8*
+  ret i8* %cb
+End:
+  ret i8* null
+}
+
+define i8* @callee(i8* %a, i8* %b) noinline {
+  ret i8* %a
+}