Index: cfe/trunk/lib/Driver/ToolChains/Clang.cpp
===================================================================
--- cfe/trunk/lib/Driver/ToolChains/Clang.cpp
+++ cfe/trunk/lib/Driver/ToolChains/Clang.cpp
@@ -3625,7 +3625,11 @@
       options::OPT_finstrument_function_entry_bare))
     A->render(Args, CmdArgs);
 
-  addPGOAndCoverageFlags(C, D, Output, Args, CmdArgs);
+  // NVPTX doesn't support PGO or coverage. There's no runtime support for
+  // sampling, overhead of call arc collection is way too high and there's no
+  // way to collect the output.
+  if (!Triple.isNVPTX())
+    addPGOAndCoverageFlags(C, D, Output, Args, CmdArgs);
 
   if (auto *ABICompatArg = Args.getLastArg(options::OPT_fclang_abi_compat_EQ))
     ABICompatArg->render(Args, CmdArgs);
Index: cfe/trunk/test/Driver/cuda-no-pgo-or-coverage.cu
===================================================================
--- cfe/trunk/test/Driver/cuda-no-pgo-or-coverage.cu
+++ cfe/trunk/test/Driver/cuda-no-pgo-or-coverage.cu
@@ -0,0 +1,34 @@
+// Check that profiling/coverage arguments doen't get passed down to device-side
+// compilation.
+//
+// REQUIRES: clang-driver
+//
+// XRUN: %clang -### -target x86_64-linux-gnu -c --cuda-gpu-arch=sm_20 \
+// XRUN:   -fprofile-generate %s 2>&1 | \
+// XRUN: FileCheck --check-prefixes=CHECK,PROF %s
+//
+// RUN: %clang -### -target x86_64-linux-gnu -c --cuda-gpu-arch=sm_20 \
+// RUN:   -fprofile-instr-generate %s 2>&1 | \
+// RUN: FileCheck --check-prefixes=CHECK,PROF %s
+//
+// RUN: %clang -### -target x86_64-linux-gnu -c --cuda-gpu-arch=sm_20 \
+// RUN:   -coverage %s 2>&1 | \
+// RUN: FileCheck --check-prefixes=CHECK,GCOV %s
+//
+// RUN: %clang -### -target x86_64-linux-gnu -c --cuda-gpu-arch=sm_20 \
+// RUN:   -ftest-coverage %s 2>&1 | \
+// RUN: FileCheck --check-prefixes=CHECK,GCOV %s
+//
+// RUN: %clang -### -target x86_64-linux-gnu -c --cuda-gpu-arch=sm_20   \
+// RUN:   -fprofile-instr-generate -fcoverage-mapping %s 2>&1 | \
+// RUN: FileCheck --check-prefixes=CHECK,PROF,GCOV %s
+//
+//
+// CHECK-NOT: error: unsupported option '-fprofile
+// CHECK-NOT: error: invalid argument
+// CHECK-DAG: "-fcuda-is-device"
+// CHECK-NOT: "-f{{[^"]*coverage.*}}"
+// CHECK-NOT: "-fprofile{{[^"]*}}"
+// CHECK: "-triple" "x86_64--linux-gnu"
+// PROF-DAG: "-fprofile{{.*}}"
+// GCOV-DAG: "-f{{(coverage|emit-coverage).*}}"