Index: lib/Transforms/Scalar/InferAddressSpaces.cpp
===================================================================
--- lib/Transforms/Scalar/InferAddressSpaces.cpp
+++ lib/Transforms/Scalar/InferAddressSpaces.cpp
@@ -971,6 +971,11 @@
         if (AddrSpaceCastInst *ASC = dyn_cast<AddrSpaceCastInst>(CurUser)) {
           unsigned NewAS = NewV->getType()->getPointerAddressSpace();
           if (ASC->getDestAddressSpace() == NewAS) {
+            if (ASC->getType()->getPointerElementType() !=
+                NewV->getType()->getPointerElementType()) {
+              NewV = CastInst::Create(Instruction::BitCast, NewV,
+                                      ASC->getType(), "", ASC);
+            }
             ASC->replaceAllUsesWith(NewV);
             DeadInstructions.push_back(ASC);
             continue;
Index: test/Transforms/InferAddressSpaces/AMDGPU/infer-addrspacecast.ll
===================================================================
--- test/Transforms/InferAddressSpaces/AMDGPU/infer-addrspacecast.ll
+++ test/Transforms/InferAddressSpaces/AMDGPU/infer-addrspacecast.ll
@@ -15,6 +15,19 @@
   ret void
 }
 
+; CHECK-LABEL: @addrspacecast_different_pointee_type(
+; CHECK: [[GEP:%.*]] = getelementptr i32, i32 addrspace(3)* %ptr, i64 9
+; CHECK: [[CAST:%.*]] = bitcast i32 addrspace(3)* [[GEP]] to i8 addrspace(3)*
+; CHECK-NEXT: store i8 8, i8 addrspace(3)* [[CAST]], align 8
+; CHECK-NEXT: ret void
+define void @addrspacecast_different_pointee_type(i32 addrspace(3)* %ptr) {
+  %asc0 = addrspacecast i32 addrspace(3)* %ptr to i32 addrspace(4)*
+  %gep0 = getelementptr i32, i32 addrspace(4)* %asc0, i64 9
+  %asc1 = addrspacecast i32 addrspace(4)* %gep0 to i8 addrspace(3)*
+  store i8 8, i8 addrspace(3)* %asc1, align 8
+  ret void
+}
+
 ; CHECK-LABEL: @addrspacecast_to_memory(
 ; CHECK: %gep0 = getelementptr i32, i32 addrspace(3)* %ptr, i64 9
 ; CHECK-NEXT: store volatile i32 addrspace(3)* %gep0, i32 addrspace(3)* addrspace(1)* undef