Index: lib/IR/ConstantFold.cpp
===================================================================
--- lib/IR/ConstantFold.cpp
+++ lib/IR/ConstantFold.cpp
@@ -620,6 +620,8 @@
       return ConstantPointerNull::get(cast<PointerType>(DestTy));
     return nullptr;                   // Other pointer types cannot be casted
   case Instruction::PtrToInt:   // always treated as unsigned
+    if (V->getType()->isVectorTy())
+      return nullptr;
     // Is it a null pointer value?
     if (V->isNullValue())
       return ConstantInt::get(DestTy, 0);
Index: test/Analysis/ConstantFolding/cast-vector.ll
===================================================================
--- /dev/null
+++ test/Analysis/ConstantFolding/cast-vector.ll
@@ -0,0 +1,17 @@
+; NOTE: Assertions have been autogenerated by utils/update_test_checks.py
+; RUN: opt < %s -instsimplify -S | FileCheck %s
+
+; The GEP is a Constant value, but the ptrtoint operand is not an isa<ConstantVector>.
+; This used to crash due to not supporting vectors in llvm::ConstantFoldCastInstruction
+; when handling the ptrtoint.
+define <2 x i16> @test1() {
+; CHECK-LABEL: @test1(
+; CHECK-NEXT:  entry:
+; CHECK-NEXT:    ret <2 x i16> ptrtoint (<2 x i32*> getelementptr ([10 x i32], [10 x i32]* null, <2 x i64> zeroinitializer, <2 x i64> <i64 5, i64 7>) to <2 x i16>)
+;
+entry:
+  %gep = getelementptr inbounds [10 x i32], [10 x i32]* null, i16 0, <2 x i16> <i16 5, i16 7>
+  %vec = ptrtoint <2 x i32*> %gep to <2 x i16>
+  ret <2 x i16> %vec
+}
+