Index: bindings/python/clang/cindex.py
===================================================================
--- bindings/python/clang/cindex.py
+++ bindings/python/clang/cindex.py
@@ -94,6 +94,9 @@
                 return cls(param)
             if isinstance(param, bytes):
                 return cls(param)
+            if param is None:
+                # Support passing null to C functions expecting char arrays
+                return None
             raise TypeError("Cannot convert '{}' to '{}'".format(type(param).__name__, cls.__name__))
 
         @staticmethod
Index: bindings/python/tests/cindex/test_index.py
===================================================================
--- bindings/python/tests/cindex/test_index.py
+++ bindings/python/tests/cindex/test_index.py
@@ -13,3 +13,5 @@
     assert isinstance(index, Index)
     tu = index.parse(os.path.join(kInputsDir, 'hello.cpp'))
     assert isinstance(tu, TranslationUnit)
+    tu = index.parse(None, ['-c', os.path.join(kInputsDir, 'hello.cpp')])
+    assert isinstance(tu, TranslationUnit)