diff --git a/clang/lib/StaticAnalyzer/Checkers/PthreadLockChecker.cpp b/clang/lib/StaticAnalyzer/Checkers/PthreadLockChecker.cpp
--- a/clang/lib/StaticAnalyzer/Checkers/PthreadLockChecker.cpp
+++ b/clang/lib/StaticAnalyzer/Checkers/PthreadLockChecker.cpp
@@ -66,7 +66,8 @@
 };
 
 class PthreadLockChecker
-    : public Checker<check::PostCall, check::DeadSymbols> {
+    : public Checker<check::PostCall, check::DeadSymbols,
+                     check::RegionChanges> {
   BugType BT_doublelock{this, "Double locking", "Lock checker"},
           BT_doubleunlock{this, "Double unlocking", "Lock checker"},
           BT_destroylock{this, "Use destroyed lock", "Lock checker"},
@@ -155,6 +156,11 @@
 public:
   void checkPostCall(const CallEvent &Call, CheckerContext &C) const;
   void checkDeadSymbols(SymbolReaper &SymReaper, CheckerContext &C) const;
+  ProgramStateRef
+  checkRegionChanges(ProgramStateRef State, const InvalidatedSymbols *Symbols,
+                     ArrayRef<const MemRegion *> ExplicitRegions,
+                     ArrayRef<const MemRegion *> Regions,
+                     const LocationContext *LCtx, const CallEvent *Call) const;
   void printState(raw_ostream &Out, ProgramStateRef State,
                   const char *NL, const char *Sep) const override;
 };
@@ -546,6 +552,42 @@
   C.addTransition(State);
 }
 
+ProgramStateRef PthreadLockChecker::checkRegionChanges(
+    ProgramStateRef State, const InvalidatedSymbols *Symbols,
+    ArrayRef<const MemRegion *> ExplicitRegions,
+    ArrayRef<const MemRegion *> Regions, const LocationContext *LCtx,
+    const CallEvent *Call) const {
+
+  bool IsLibraryFunction = false;
+  if (Call && Call->isGlobalCFunction()) {
+    // Avoid invalidating mutex state when a known supported function is called.
+    if (Callbacks.lookup(*Call))
+        return State;
+
+    if (Call->isInSystemHeader())
+      IsLibraryFunction = true;
+  }
+
+  for (auto R : Regions) {
+    // We assume that system library function wouldn't touch the mutex unless
+    // it takes the mutex explicitly as an argument.
+    // FIXME: This is a bit quadratic.
+    if (IsLibraryFunction &&
+        std::find(ExplicitRegions.begin(), ExplicitRegions.end(), R) ==
+            ExplicitRegions.end())
+      continue;
+
+    State = State->remove<LockMap>(R);
+    State = State->remove<DestroyRetVal>(R);
+
+    // TODO: We need to invalidate the lock stack as well. This is tricky
+    // to implement correctly and efficiently though, because the effects
+    // of mutex escapes on lock order may be fairly varied.
+  }
+
+  return State;
+}
+
 void ento::registerPthreadLockChecker(CheckerManager &mgr) {
   mgr.registerChecker<PthreadLockChecker>();
 }
diff --git a/clang/test/Analysis/Inputs/system-header-simulator-for-pthread-lock.h b/clang/test/Analysis/Inputs/system-header-simulator-for-pthread-lock.h
--- a/clang/test/Analysis/Inputs/system-header-simulator-for-pthread-lock.h
+++ b/clang/test/Analysis/Inputs/system-header-simulator-for-pthread-lock.h
@@ -21,6 +21,9 @@
 
 typedef pthread_mutex_t lck_mtx_t;
 
+extern void fake_system_function();
+extern void fake_system_function_that_takes_a_mutex(pthread_mutex_t *mtx);
+
 extern int pthread_mutex_lock(pthread_mutex_t *);
 extern int pthread_mutex_unlock(pthread_mutex_t *);
 extern int pthread_mutex_trylock(pthread_mutex_t *);
diff --git a/clang/test/Analysis/pthreadlock.c b/clang/test/Analysis/pthreadlock.c
--- a/clang/test/Analysis/pthreadlock.c
+++ b/clang/test/Analysis/pthreadlock.c
@@ -221,6 +221,27 @@
   lck_rw_unlock_exclusive(&rw); // no-warning
 }
 
+void escape_mutex(pthread_mutex_t *m);
+void ok30(void) {
+  pthread_mutex_t local_mtx;
+  pthread_mutex_init(&local_mtx, NULL);
+  pthread_mutex_lock(&local_mtx);
+  escape_mutex(&local_mtx);
+  pthread_mutex_lock(&local_mtx); // no-warning
+  pthread_mutex_unlock(&local_mtx);
+  pthread_mutex_destroy(&local_mtx);
+}
+
+void ok31(void) {
+  pthread_mutex_t local_mtx;
+  pthread_mutex_init(&local_mtx, NULL);
+  pthread_mutex_lock(&local_mtx);
+  fake_system_function_that_takes_a_mutex(&local_mtx);
+  pthread_mutex_lock(&local_mtx); // no-warning
+  pthread_mutex_unlock(&local_mtx);
+  pthread_mutex_destroy(&local_mtx);
+}
+
 void
 bad1(void)
 {
@@ -486,3 +507,9 @@
   lck_rw_lock_exclusive(&rw);
   lck_rw_unlock_shared(&rw); // FIXME: warn - should be exclusive?
 }
+
+void bad33(void) {
+  pthread_mutex_lock(pmtx);
+  fake_system_function();
+  pthread_mutex_lock(pmtx); // expected-warning{{This lock has already been acquired}}
+}