Index: lib/Target/WebAssembly/WebAssemblyFastISel.cpp
===================================================================
--- lib/Target/WebAssembly/WebAssemblyFastISel.cpp
+++ lib/Target/WebAssembly/WebAssemblyFastISel.cpp
@@ -700,9 +700,12 @@
   if (Func && Func->isIntrinsic())
     return false;
 
+  bool IsDirect = Func != nullptr;
+  if (!IsDirect && isa<ConstantExpr>(Call->getCalledValue()))
+    return false;
+
   FunctionType *FuncTy = Call->getFunctionType();
   unsigned Opc;
-  bool IsDirect = Func != nullptr;
   bool IsVoid = FuncTy->getReturnType()->isVoidTy();
   unsigned ResultReg;
   if (IsVoid) {
Index: test/CodeGen/WebAssembly/call.ll
===================================================================
--- test/CodeGen/WebAssembly/call.ll
+++ test/CodeGen/WebAssembly/call.ll
@@ -150,6 +150,22 @@
   ret void
 }
 
+; CHECK-LABEL: call_constexpr:
+; CHECK-NEXT: i32.const $push[[L0:[0-9]+]]=, 2{{$}}
+; CHECK-NEXT: i32.const $push[[L1:[0-9]+]]=, 3{{$}}
+; CHECK-NEXT: call vararg_func@FUNCTION, $pop[[L0]], $pop[[L1]]{{$}}
+; CHECK-NEXT: call other_void_nullary@FUNCTION{{$}}
+; CHECK-NEXT: call void_nullary@FUNCTION{{$}}
+; CHECK-NEXT: return{{$}}
+declare void @vararg_func(...)
+declare void @other_void_nullary()
+define void @call_constexpr() {
+  call void bitcast (void (...)* @vararg_func to void (i32, i32)*)(i32 2, i32 3)
+  call void select (i1 0, void ()* @void_nullary, void ()* @other_void_nullary)()
+  call void inttoptr (i32 ptrtoint (void ()* @void_nullary to i32) to void ()*)()
+  ret void
+}
+
 ; TODO: test the following:
 ;  - More argument combinations.
 ;  - Tail call.