Index: lib/Transforms/IPO/GlobalOpt.cpp
===================================================================
--- lib/Transforms/IPO/GlobalOpt.cpp
+++ lib/Transforms/IPO/GlobalOpt.cpp
@@ -2026,6 +2026,17 @@
       continue;
     }
 
+    // LLVM's definition of dominance allows instructions that are cyclic
+    // in unreachable blocks, e.g.:
+    // %pat = select i1 %condition, @global, i16* %pat
+    // because any instruction dominates an instruction in a block that's
+    // not reachable from entry.
+    // So, remove unreachable blocks from the function, because a) there's
+    // no point in analyzing them and b) GlobalOpt should otherwise grow
+    // some more complicated logic to break these cycles.
+    if (!F->isDeclaration())
+      Changed |= removeUnreachableBlocks(*F);
+
     Changed |= processGlobal(*F, TLI, LookupDomTree);
 
     if (!F->hasLocalLinkage())
Index: test/Transforms/GlobalOpt/pr33686.ll
===================================================================
--- /dev/null
+++ test/Transforms/GlobalOpt/pr33686.ll
@@ -0,0 +1,17 @@
+; RUN: opt -S -globalopt %s | FileCheck %s
+
+; CHECK-LABEL: define void @beth
+; CHECK-NEXT:   entry:
+; CHECK-NEXT:   ret void
+; CHEC-NEXT:  }
+
+@glob = external global i16, align 1
+
+define void @beth() {
+entry:
+  ret void
+
+notreachable:
+  %patatino = select i1 undef, i16* @glob, i16* %patatino
+  br label %notreachable
+}