Index: lib/Transforms/Utils/SimplifyIndVar.cpp
===================================================================
--- lib/Transforms/Utils/SimplifyIndVar.cpp
+++ lib/Transforms/Utils/SimplifyIndVar.cpp
@@ -262,6 +262,10 @@
     ICmp->setPredicate(InvariantPredicate);
     ICmp->setOperand(0, NewLHS);
     ICmp->setOperand(1, NewRHS);
+  } else if (Pred != ICmpInst::getUnsignedPredicate(Pred) &&
+             SE->isKnownNonNegative(S) && SE->isKnownNonNegative(X)) {
+    DEBUG(dbgs() << "INDVARS: Turn to unsigned comparison: " << *ICmp << '\n');
+    ICmp->setPredicate(ICmpInst::getUnsignedPredicate(Pred));
   } else
     return;
 
Index: test/Analysis/ScalarEvolution/guards.ll
===================================================================
--- test/Analysis/ScalarEvolution/guards.ll
+++ test/Analysis/ScalarEvolution/guards.ll
@@ -19,7 +19,7 @@
 loop:
 ; CHECK: loop:
 ; CHECK:  call void (i1, ...) @llvm.experimental.guard(i1 true) [ "deopt"() ]
-; CHECK:  %iv.inc.cmp = icmp slt i32 %iv.inc, %len
+; CHECK:  %iv.inc.cmp = icmp ult i32 %iv.inc, %len
 ; CHECK:  call void (i1, ...) @llvm.experimental.guard(i1 %iv.inc.cmp) [ "deopt"() ]
 ; CHECK: leave:
 
@@ -41,7 +41,7 @@
 
 define void @test_2(i32 %n, i32* %len_buf) {
 ; CHECK-LABEL: @test_2(
-; CHECK:  [[LEN_SEXT:%[^ ]+]] = sext i32 %len to i64
+; CHECK:  [[LEN_ZEXT:%[^ ]+]] = zext i32 %len to i64
 ; CHECK:  br label %loop
 
 entry:
@@ -52,7 +52,7 @@
 ; CHECK: loop:
 ; CHECK:  %indvars.iv = phi i64 [ %indvars.iv.next, %loop ], [ 0, %entry ]
 ; CHECK:  %indvars.iv.next = add nuw nsw i64 %indvars.iv, 1
-; CHECK:  %iv.inc.cmp = icmp slt i64 %indvars.iv.next, [[LEN_SEXT]]
+; CHECK:  %iv.inc.cmp = icmp ult i64 %indvars.iv.next, [[LEN_ZEXT]]
 ; CHECK:  call void (i1, ...) @llvm.experimental.guard(i1 %iv.inc.cmp) [ "deopt"() ]
 ; CHECK: leave:
 
Index: test/Transforms/IndVarSimplify/canonicalize-cmp.ll
===================================================================
--- test/Transforms/IndVarSimplify/canonicalize-cmp.ll
+++ test/Transforms/IndVarSimplify/canonicalize-cmp.ll
@@ -0,0 +1,52 @@
+; RUN: opt -S -indvars < %s | FileCheck %s
+
+; Check that we replace signed comparisons between non-negative values with
+; unsigned comparisons if we can.
+
+target datalayout = "n8:16:32:64"
+
+define i32 @test_01(i32 %a, i32 %b, i32* %p) {
+
+; CHECK-LABEL: @test_01(
+; CHECK-NOT:   icmp slt
+; CHECK:       %cmp1 = icmp ult i32 %iv, 100
+; CHECK:       %cmp2 = icmp ult i32 %iv, 100
+; CHECK-NOT:   %cmp3
+; CHECK:       %exitcond = icmp ne i32 %iv.next, 1000
+
+entry:
+  br label %loop.entry
+
+loop.entry:
+  %iv = phi i32 [ 0, %entry ], [ %iv.next, %loop.be ]
+  %cmp1 = icmp slt i32 %iv, 100
+  br i1 %cmp1, label %b1, label %b2
+
+b1:
+  store i32 %iv, i32* %p
+  br label %merge
+
+b2:
+  store i32 %a, i32* %p
+  br label %merge
+
+merge:
+  %cmp2 = icmp ult i32 %iv, 100
+  br i1 %cmp2, label %b3, label %b4
+
+b3:
+  store i32 %iv, i32* %p
+  br label %loop.be
+
+b4:
+  store i32 %b, i32* %p
+  br label %loop.be
+
+loop.be:
+  %iv.next = add i32 %iv, 1
+  %cmp3 = icmp slt i32 %iv.next, 1000
+  br i1 %cmp3, label %loop.entry, label %exit
+
+exit:
+  ret i32 %iv
+}
Index: test/Transforms/IndVarSimplify/eliminate-comparison.ll
===================================================================
--- test/Transforms/IndVarSimplify/eliminate-comparison.ll
+++ test/Transforms/IndVarSimplify/eliminate-comparison.ll
@@ -111,7 +111,7 @@
 ; Indvars should not turn the second loop into an infinite one.
 
 ; CHECK-LABEL: @func_11(
-; CHECK: %tmp5 = icmp slt i32 %__key6.0, 10
+; CHECK: %tmp5 = icmp ult i32 %__key6.0, 10
 ; CHECK-NOT: br i1 true, label %noassert68, label %unrolledend
 
 define i32 @func_11() nounwind uwtable {
@@ -163,7 +163,7 @@
 
 ; In this case the second loop only has a single iteration, fold the header away
 ; CHECK-LABEL: @func_12(
-; CHECK: %tmp5 = icmp slt i32 %__key6.0, 10
+; CHECK: %tmp5 = icmp ult i32 %__key6.0, 10
 ; CHECK: br i1 true, label %noassert68, label %unrolledend
 define i32 @func_12() nounwind uwtable {
 entry:
Index: test/Transforms/IndVarSimplify/widen-loop-comp.ll
===================================================================
--- test/Transforms/IndVarSimplify/widen-loop-comp.ll
+++ test/Transforms/IndVarSimplify/widen-loop-comp.ll
@@ -64,7 +64,7 @@
 ; CHECK-LABEL: @test2
 ; CHECK: for.body4.us
 ; CHECK: %indvars.iv.next = add nuw nsw i64 %indvars.iv, 1
-; CHECK: %cmp2.us = icmp slt i64
+; CHECK: %cmp2.us = icmp ult i64
 ; CHECK-NOT: %2 = trunc i64 %indvars.iv.next to i32
 ; CHECK-NOT: %cmp2.us = icmp slt i32