Index: lib/Target/AMDGPU/AMDGPUTargetMachine.cpp
===================================================================
--- lib/Target/AMDGPU/AMDGPUTargetMachine.cpp
+++ lib/Target/AMDGPU/AMDGPUTargetMachine.cpp
@@ -244,6 +244,7 @@
         }));
         PM.add(createGlobalDCEPass());
       }
+      PM.add(createAMDGPUAlwaysInlinePass());
   });
 }
 
Index: test/CodeGen/AMDGPU/early-inline.ll
===================================================================
--- /dev/null
+++ test/CodeGen/AMDGPU/early-inline.ll
@@ -0,0 +1,21 @@
+; RUN: opt -mtriple=amdgcn-- -O1 -S -inline-threshold=1 %s | FileCheck %s
+
+define i32 @callee(i32 %x) {
+entry:
+  %mul1 = mul i32 %x, %x
+  %mul2 = mul i32 %mul1, %x
+  %mul3 = mul i32 %mul1, %mul2
+  %mul4 = mul i32 %mul3, %mul2
+  %mul5 = mul i32 %mul4, %mul3
+  ret i32 %mul5
+}
+
+; CHECK-LABEL: @caller
+; CHECK: mul i32
+; CHECK-NOT: call i32
+
+define i32 @caller(i32 %x) {
+entry:
+  %res = call i32 @callee(i32 %x)
+  ret i32 %res
+}