Index: lib/Analysis/ValueTracking.cpp
===================================================================
--- lib/Analysis/ValueTracking.cpp
+++ lib/Analysis/ValueTracking.cpp
@@ -1025,7 +1025,6 @@
     break; // Can't work with floating point.
   case Instruction::PtrToInt:
   case Instruction::IntToPtr:
-  case Instruction::AddrSpaceCast: // Pointers could be different sizes.
     // Fall through and handle them the same as zext/trunc.
     LLVM_FALLTHROUGH;
   case Instruction::ZExt:
Index: test/Analysis/ValueTracking/knownzero-addrspacecast.ll
===================================================================
--- /dev/null
+++ test/Analysis/ValueTracking/knownzero-addrspacecast.ll
@@ -0,0 +1,24 @@
+; RUN: opt -instcombine -S < %s | FileCheck %s
+
+; When a pointer is addrspacecasted to a another addr space, we cannot assume
+; anything about the new bits.
+
+target datalayout = "p:32:32-p3:32:32-p4:64:64"
+
+; CHECK-LABEL: @test_shift
+; CHECK-NOT: ret i64 0
+define i64 @test_shift(i8* %p) {
+  %g = addrspacecast i8* %p to i8 addrspace(4)*
+  %i = ptrtoint i8 addrspace(4)* %g to i64
+  %shift = lshr i64 %i, 32
+  ret i64 %shift
+}
+
+; CHECK-LABEL: @test_null
+; A null pointer casted to another addr space may no longer have null value.
+; CHECK-NOT: ret i32 0
+define i32 @test_null() {
+  %g = addrspacecast i8* null to i8 addrspace(3)*
+  %i = ptrtoint i8 addrspace(3)* %g to i32
+  ret i32 %i
+}
\ No newline at end of file
Index: test/Transforms/InstCombine/loadstore-alignment.ll
===================================================================
--- test/Transforms/InstCombine/loadstore-alignment.ll
+++ test/Transforms/InstCombine/loadstore-alignment.ll
@@ -14,33 +14,6 @@
   ret <2 x i64> %tmp1
 }
 
-; CHECK-LABEL: @static_hem_addrspacecast(
-; CHECK: , align 16
-define <2 x i64> @static_hem_addrspacecast() {
-  %t = getelementptr <2 x i64>, <2 x i64>* @x, i32 7
-  %t.asc = addrspacecast <2 x i64>* %t to <2 x i64> addrspace(1)*
-  %tmp1 = load <2 x i64>, <2 x i64> addrspace(1)* %t.asc, align 1
-  ret <2 x i64> %tmp1
-}
-
-; CHECK-LABEL: @static_hem_addrspacecast_smaller_ptr(
-; CHECK: , align 16
-define <2 x i64> @static_hem_addrspacecast_smaller_ptr() {
-  %t = getelementptr <2 x i64>, <2 x i64>* @x, i32 7
-  %t.asc = addrspacecast <2 x i64>* %t to <2 x i64> addrspace(2)*
-  %tmp1 = load <2 x i64>, <2 x i64> addrspace(2)* %t.asc, align 1
-  ret <2 x i64> %tmp1
-}
-
-; CHECK-LABEL: @static_hem_addrspacecast_larger_ptr(
-; CHECK: , align 16
-define <2 x i64> @static_hem_addrspacecast_larger_ptr() {
-  %t = getelementptr <2 x i64>, <2 x i64> addrspace(2)* @x.as2, i32 7
-  %t.asc = addrspacecast <2 x i64> addrspace(2)* %t to <2 x i64> addrspace(1)*
-  %tmp1 = load <2 x i64>, <2 x i64> addrspace(1)* %t.asc, align 1
-  ret <2 x i64> %tmp1
-}
-
 ; CHECK-LABEL: @hem(
 ; CHECK: , align 16
 define <2 x i64> @hem(i32 %i) {