Index: lib/Transforms/InstCombine/InstCombineCalls.cpp
===================================================================
--- lib/Transforms/InstCombine/InstCombineCalls.cpp
+++ lib/Transforms/InstCombine/InstCombineCalls.cpp
@@ -2243,7 +2243,10 @@
     break;
   }
   case Intrinsic::lifetime_start:
-    if (removeTriviallyEmptyRange(*II, Intrinsic::lifetime_start,
+    // Asan needs to poison memory to detect invalid access which is possible
+    // even for empty lifetime range.
+    if (!II->getFunction()->hasFnAttribute(Attribute::SanitizeAddress) &&
+        removeTriviallyEmptyRange(*II, Intrinsic::lifetime_start,
                                   Intrinsic::lifetime_end, *this))
       return nullptr;
     break;
Index: test/Transforms/InstCombine/lifetime-asan.ll
===================================================================
--- /dev/null
+++ test/Transforms/InstCombine/lifetime-asan.ll
@@ -0,0 +1,35 @@
+; RUN: opt < %s -instcombine -S | FileCheck %s
+
+declare void @llvm.lifetime.start(i64, i8* nocapture)
+declare void @llvm.lifetime.end(i64, i8* nocapture)
+declare void @foo(i8* nocapture)
+
+define void @asan() sanitize_address {
+entry:
+  ; CHECK-LABEL: @asan(
+  %text = alloca i8, align 1
+
+  call void @llvm.lifetime.start(i64 1, i8* %text)
+  call void @llvm.lifetime.end(i64 1, i8* %text)
+  ; CHECK: call void @llvm.lifetime.start
+  ; CHECK-NEXT: call void @llvm.lifetime.end
+
+  call void @foo(i8* %text) ; Keep alloca alive
+
+  ret void
+}
+
+
+define void @no_asan() {
+entry:
+  ; CHECK-LABEL: @no_asan(
+  %text = alloca i8, align 1
+
+  call void @llvm.lifetime.start(i64 1, i8* %text)
+  call void @llvm.lifetime.end(i64 1, i8* %text)
+  ; CHECK-NO: call void @llvm.lifetime
+
+  call void @foo(i8* %text) ; Keep alloca alive
+
+  ret void
+}